Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor

The transcription factor Nrf2 (encoded by Nfe2l2) induces expression of numerous detoxifying and antioxidant genes in response to oxidative stress. The cytoplasmic protein Keap1 interacts with and represses Nrf2 function. Computational approaches were developed to identify factors that modulate Nrf2...

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Detalles Bibliográficos
Autores principales: Rooney, John, Oshida, Keiyu, Vasani, Naresh, Vallanat, Beena, Ryan, Natalia, Chorley, Brian N., Wang, Xuting, Bell, Douglas A., Wu, Kai C., Aleksunes, Lauren M., Klaassen, Curtis D., Kensler, Thomas W., Corton, J. Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095522/
https://www.ncbi.nlm.nih.gov/pubmed/30114225
http://dx.doi.org/10.1371/journal.pone.0200004

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