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High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells

In the biopharmaceutical sector, Chinese hamster ovary (CHO) cells have become the host of choice to produce recombinant proteins (r-proteins) due to their capacity for correct protein folding, assembly, and posttranslational modification. However, the production of therapeutic r-proteins in CHO cel...

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Detalles Bibliográficos
Autores principales:	Vergara, Mauricio, Torres, Mauro, Müller, Andrea, Avello, Verónica, Acevedo, Cristian, Berrios, Julio, Reyes, Juan G., Valdez-Cruz, Norma A., Altamirano, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095543/ https://www.ncbi.nlm.nih.gov/pubmed/30114204 http://dx.doi.org/10.1371/journal.pone.0202098

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