Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction

Deubiquitinating enzymes (DUBs) remove ubiquitin from their substrates and, together with ubiquitin ligases, play an important role in the regulation of protein expression. Although transforming growth factor (TGF)-β1-Smad signaling is a central pathway of renal fibrosis, the role of DUBs in the exp...

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Detalles Bibliográficos
Autores principales: Soji, Kotaro, Doi, Shigehiro, Nakashima, Ayumu, Sasaki, Kensuke, Doi, Toshiki, Masaki, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095583/
https://www.ncbi.nlm.nih.gov/pubmed/30114247
http://dx.doi.org/10.1371/journal.pone.0202409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095583/
https://www.ncbi.nlm.nih.gov/pubmed/30114247
http://dx.doi.org/10.1371/journal.pone.0202409

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