Cargando…

Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction

Deubiquitinating enzymes (DUBs) remove ubiquitin from their substrates and, together with ubiquitin ligases, play an important role in the regulation of protein expression. Although transforming growth factor (TGF)-β1-Smad signaling is a central pathway of renal fibrosis, the role of DUBs in the exp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Soji, Kotaro, Doi, Shigehiro, Nakashima, Ayumu, Sasaki, Kensuke, Doi, Toshiki, Masaki, Takao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095583/ https://www.ncbi.nlm.nih.gov/pubmed/30114247 http://dx.doi.org/10.1371/journal.pone.0202409

Ejemplares similares

TGF-β1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA
por: Shindo, Toshihiro, et al.
Publicado: (2018)

Linagliptin Ameliorates Methylglyoxal-Induced Peritoneal Fibrosis in Mice
por: Nagai, Takuo, et al.
Publicado: (2016)

Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis
por: Tamura, Ryo, et al.
Publicado: (2018)

microRNA-200c regulates KLOTHO expression in human kidney cells under oxidative stress
por: Morii, Kenichi, et al.
Publicado: (2019)

Klotho deficiency intensifies hypoxia-induced expression of IFN-α/β through upregulation of RIG-I in kidneys
por: Urabe, Asako, et al.
Publicado: (2021)

Upregulation of Mineralocorticoid Receptor Contributes to Development of Salt-Sensitive Hypertension after Ischemia–Reperfusion Injury in Rats
por: Matsumoto, Takumi, et al.
Publicado: (2022)

Mizoribine Ameliorates Renal Injury and Hypertension along with the Attenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats
por: Doi, Toshiki, et al.
Publicado: (2014)

Hypoxia-preconditioned mesenchymal stem cells prevent renal fibrosis and inflammation in ischemia-reperfusion rats
por: Ishiuchi, Naoki, et al.
Publicado: (2020)

Interferon-γ enhances the therapeutic effect of mesenchymal stem cells on experimental renal fibrosis
por: Kanai, Ryo, et al.
Publicado: (2021)

Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-β1 signaling
por: Ueno, Toshinori, et al.
Publicado: (2013)

Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis
por: Maeda, Kazuya, et al.
Publicado: (2017)

High-normal albuminuria is associated with subclinical atherosclerosis in male population with estimated glomerular filtration rate ≥60 mL/min/1.73 m(2): A cross-sectional study
por: Kimura, Tomoe, et al.
Publicado: (2019)

Serum-free medium and hypoxic preconditioning synergistically enhance the therapeutic effects of mesenchymal stem cells on experimental renal fibrosis
por: Ishiuchi, Naoki, et al.
Publicado: (2021)

Mesenchymal stem cells cultured in serum-free medium ameliorate experimental peritoneal fibrosis
por: Nagasaki, Kohei, et al.
Publicado: (2021)

Serum‐Free Medium Enhances the Immunosuppressive and Antifibrotic Abilities of Mesenchymal Stem Cells Utilized in Experimental Renal Fibrosis
por: Yoshida, Ken, et al.
Publicado: (2018)

Lower Geriatric Nutritional Risk Index (GNRI) Is Associated with Higher Risk of Fractures in Patients Undergoing Hemodialysis
por: Yoshida, Maria, et al.
Publicado: (2021)

Localization and Maintenance of Engrafted Mesenchymal Stem Cells Administered via Renal Artery in Kidneys with Ischemia-Reperfusion Injury
por: Yamada, Yumi, et al.
Publicado: (2021)

The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison
por: Cowell, Ian G., et al.
Publicado: (2019)

A case report of atypical anti-glomerular basement membrane disease
por: Tamura, Ryo, et al.
Publicado: (2022)

Oleanolic Acid Attenuates Renal Fibrosis through TGF-β/Smad Pathway in a Rat Model of Unilateral Ureteral Obstruction
por: Zhao, Dapeng, et al.
Publicado: (2020)

The Smad3-dependent microRNA let-7i-5p promoted renal fibrosis in mice with unilateral ureteral obstruction
por: Peng, Ze, et al.
Publicado: (2022)

Iron, coronary artery calcification, and mortality in patients undergoing hemodialysis
por: Mizuiri, Sonoo, et al.
Publicado: (2021)

Clinical characteristics of inflammatory bowel disease patients with immunoglobulin A nephropathy
por: Hayashi, Ryohei, et al.
Publicado: (2021)

Specific Inhibitor of Smad3 (SIS3) Attenuates Fibrosis, Apoptosis, and Inflammation in Unilateral Ureteral Obstruction Kidneys by Inhibition of Transforming Growth Factor β (TGF-β)/Smad3 Signaling
por: Ji, Xingli, et al.
Publicado: (2018)

Effects of exendin-4 on the intrarenal renin-angiotensin system and interstitial fibrosis in unilateral ureteral obstruction mice: Exendin-4 and unilateral ureteral obstruction
por: Le, Ying, et al.
Publicado: (2016)

FFNT25 ameliorates unilateral ureteral obstruction-induced renal fibrosis
por: Li, Wen, et al.
Publicado: (2019)

Unilateral Ureteral Obstruction as a Model to Investigate Fibrosis-Attenuating Treatments
por: Martínez-Klimova, Elena, et al.
Publicado: (2019)

AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction
por: Landolt, Lea, et al.
Publicado: (2019)

Kidney-Draining Lymph Node Fibrosis Following Unilateral Ureteral Obstruction
por: Li, Xiaofei, et al.
Publicado: (2021)

Protective effects of quercetin and hyperoside on renal fibrosis in rats with unilateral ureteral obstruction
por: YAN, YANG, et al.
Publicado: (2014)

L-Endoglin Overexpression Increases Renal Fibrosis after Unilateral Ureteral Obstruction
por: Oujo, Bárbara, et al.
Publicado: (2014)

Mefunidone Attenuates Tubulointerstitial Fibrosis in a Rat Model of Unilateral Ureteral Obstruction
por: Liu, Chunyan, et al.
Publicado: (2015)

Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction
por: BABA, ITSUKO, et al.
Publicado: (2015)

The Protective Effect of Melittin on Renal Fibrosis in an Animal Model of Unilateral Ureteral Obstruction
por: An, Hyun-Jin, et al.
Publicado: (2016)

Eplerenone ameliorates lung fibrosis in unilateral ureteral obstruction rats by inhibiting lymphangiogenesis
por: Liu, Ziqian, et al.
Publicado: (2022)

Role of the high-affinity leukotriene B(4) receptor signaling in fibrosis after unilateral ureteral obstruction in mice
por: Kamata, Mariko, et al.
Publicado: (2019)

DAMPs in Unilateral Ureteral Obstruction
por: Wyczanska, Maja, et al.
Publicado: (2020)

β-Elemene Attenuates Renal Fibrosis in the Unilateral Ureteral Obstruction Model by Inhibition of STAT3 and Smad3 Signaling via Suppressing MyD88 Expression
por: Sun, Wenjuan, et al.
Publicado: (2022)

THU619 Atypical Clinical Presentation Of Adrenal Hemorrhage
por: Madsen-Barbosa, Thayse Lozovoy, et al.
Publicado: (2023)

Correction: Role of the high-affinity leukotriene B(4) receptor signaling in fibrosis after unilateral ureteral obstruction in mice
por: Kamata, Mariko, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jcc1qgqs51cqk6dnv0ap14037v