KDM5 histone demethylases repress immune response via suppression of STING

Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer. STING agonists induce both innate and adaptive immune responses and are a new class...

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Detalles Bibliográficos
Autores principales: Wu, Lizhen, Cao, Jian, Cai, Wesley L., Lang, Sabine M., Horton, John R., Jansen, Daniel J., Liu, Zongzhi Z., Chen, Jocelyn F., Zhang, Meiling, Mott, Bryan T., Pohida, Katherine, Rai, Ganesha, Kales, Stephen C., Henderson, Mark J., Hu, Xin, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Zhu, Shu, Iwasaki, Akiko, Hall, Matthew D., Cheng, Xiaodong, Shadel, Gerald S., Yan, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095604/
https://www.ncbi.nlm.nih.gov/pubmed/30080846
http://dx.doi.org/10.1371/journal.pbio.2006134

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