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Drosophila Ca(V)2 channels harboring human migraine mutations cause synapse hyperexcitability that can be suppressed by inhibition of a Ca(2+) store release pathway

Gain-of-function mutations in the human Ca(V)2.1 gene CACNA1A cause familial hemiplegic migraine type 1 (FHM1). To characterize cellular problems potentially triggered by Ca(V)2.1 gains of function, we engineered mutations encoding FHM1 amino-acid substitutions S218L (SL) and R192Q (RQ) into transge...

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Detalles Bibliográficos
Autores principales:	Brusich, Douglas J., Spring, Ashlyn M., James, Thomas D., Yeates, Catherine J., Helms, Timothy H., Frank, C. Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095605/ https://www.ncbi.nlm.nih.gov/pubmed/30080864 http://dx.doi.org/10.1371/journal.pgen.1007577

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