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Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate)

Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor used in first-line combination antiretroviral therapy (cART). It is usually administered with nucleoside reverse transcriptase inhibitors (NRTI), many of which are substrates of OCT uptake solute carriers (SLC22A) and MATE (SLC47A),...

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Detalles Bibliográficos
Autores principales:	Ceckova, Martina, Reznicek, Josef, Deutsch, Birgit, Fromm, Martin F., Staud, Frantisek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095608/ https://www.ncbi.nlm.nih.gov/pubmed/30114293 http://dx.doi.org/10.1371/journal.pone.0202706

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