Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids

Distinct transcriptional states are maintained through organization of chromatin, resulting from the sum of numerous repressive and active histone modifications, into tightly packaged heterochromatin versus more accessible euchromatin. Polycomb repressive complex 2 (PRC2) is the main mammalian compl...

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Detalles Bibliográficos
Autores principales: Michalak, Ewa M., Milevskiy, Michael J. G., Joyce, Rachel M., Dekkers, Johanna F., Jamieson, Paul R., Pal, Bhupinder, Dawson, Caleb A., Hu, Yifang, Orkin, Stuart H., Alexander, Warren S., Lindeman, Geoffrey J., Smyth, Gordon K., Visvader, Jane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095611/
https://www.ncbi.nlm.nih.gov/pubmed/30080881
http://dx.doi.org/10.1371/journal.pbio.2004986

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