Type I IFNs drive hematopoietic stem and progenitor cell collapse via impaired proliferation and increased RIPK1-dependent cell death during shock-like ehrlichial infection

Type I interferons (IFNα/β) regulate diverse aspects of host defense, but their impact on hematopoietic stem and progenitor cells (HSC/HSPCs) during infection remains unclear. Hematologic impairment can occur in severe infections, thus we sought to investigate the impact of type I IFNs on hematopoie...

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Detalles Bibliográficos
Autores principales: Smith, Julianne N. P., Zhang, Yubin, Li, Jing Jing, McCabe, Amanda, Jo, Hui Jin, Maloney, Jackson, MacNamara, Katherine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095620/
https://www.ncbi.nlm.nih.gov/pubmed/30080899
http://dx.doi.org/10.1371/journal.ppat.1007234

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