Differential Glucose Requirement in Skin Homeostasis and Injury Identifies a Therapeutic Target for Psoriasis

Proliferating cells depend on glucose uptake more than quiescent cells for their growth. While glucose transport in keratinocytes is mediated largely by the Glut1 facilitative transporter, the keratinocyte-specific ablation of Glut1 did not compromise mouse skin development and homeostasis. Ex vivo...

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Detalles Bibliográficos
Autores principales: Zhang, Zhuzhen, Zi, Zhenzhen, Lee, Eunice E., Zhao, Jiawei, Contreras, Diana C., South, Andrew P., Abel, E. Dale, Chong, Benjamin F., Vandergriff, Travis, Hosler, Gregory A., Scherer, Philipp E., Mettlen, Marcel, Rathmell, Jeffrey C., DeBerardinis, Ralph J., Wang, Richard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095711/
https://www.ncbi.nlm.nih.gov/pubmed/29662201
http://dx.doi.org/10.1038/s41591-018-0003-0

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