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Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche
Aging of hematopoietic stem cells (HSCs) is associated with a decline in their regenerative capacity and multi-lineage differentiation potential, contributing to the development of blood disorders. The bone marrow microenvironment has recently been suggested to influence HSC aging, but the underlyin...
Autores principales: | Maryanovich, Maria, Zahalka, Ali H., Pierce, Halley, Pinho, Sandra, Nakahara, Fumio, Asada, Noboru, Wei, Qiaozhi, Wang, Xizhe, Ciero, Paul, Xu, Jianing, Leftin, Avigdor, Frenette, Paul S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095812/ https://www.ncbi.nlm.nih.gov/pubmed/29736022 http://dx.doi.org/10.1038/s41591-018-0030-x |
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