MASTL overexpression promotes chromosome instability and metastasis in breast cancer

MASTL kinase is essential for correct progression through mitosis, with loss of MASTL causing chromosome segregation errors, mitotic collapse and failure of cytokinesis. However, in cancer MASTL is most commonly amplified and overexpressed. This correlates with increased chromosome instability in br...

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Detalles Bibliográficos
Autores principales: Rogers, Samuel, McCloy, Rachael A., Parker, Benjamin L., Gallego-Ortega, David, Law, Andrew M. K., Chin, Venessa T., Conway, James R. W., Fey, Dirk, Millar, Ewan K. A., O’Toole, Sandra, Deng, Niantao, Swarbrick, Alexander, Chastain, Paul D., Cesare, Anthony J., Timpson, Paul, Caldon, C. Elizabeth, Croucher, David R., James, David E., Watkins, D. Neil, Burgess, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095835/
https://www.ncbi.nlm.nih.gov/pubmed/29743597
http://dx.doi.org/10.1038/s41388-018-0295-z

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