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Hematopoietic reconstitution of neonatal immunocompetent mice to study conditions with a perinatal window of susceptibility

Efficient hematopoietic reconstitution of wild type mice requires preconditioning. Established experimental protocols exist to transplant hematopoietic stem cells into lethally irradiated or chemically myeloablated adult mice or unirradiated immunodeficient mice. We sought to develop a protocol to r...

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Detalles Bibliográficos
Autores principales: Laky, Karen, Dugan, Philip, Frischmeyer-Guerrerio, Pamela A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095844/
https://www.ncbi.nlm.nih.gov/pubmed/30115970
http://dx.doi.org/10.1038/s41598-018-30767-1

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