Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor

Exportin-1 (XPO1) controls the nucleo-cytoplasmic trafficking of several key growth regulatory and tumor suppressor proteins. Nuclear export blockade through XPO1 inhibition is a target for therapeutic inhibition in many cancers. Studies have suggested XPO1 upregulation as an indicator of poor progn...

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Detalles Bibliográficos
Autores principales: Subhash, Vinod Vijay, Yeo, Mei Shi, Wang, Lingzhi, Tan, Shi Hui, Wong, Foong Ying, Thuya, Win Lwin, Tan, Woei Loon, Peethala, Praveen C., Soe, Mu Yar, Tan, David S. P., Padmanabhan, Nisha, Baloglu, Erkan, Shacham, Sharon, Tan, Patrick, Koeffler, H. Phillip, Yong, Wei Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095850/
https://www.ncbi.nlm.nih.gov/pubmed/30115935
http://dx.doi.org/10.1038/s41598-018-30686-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095850/
https://www.ncbi.nlm.nih.gov/pubmed/30115935
http://dx.doi.org/10.1038/s41598-018-30686-1

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