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Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients
The outcomes of HBV and HCV infections are associated both with viral and host genetic factors. Here, we explore the role of a genetic variation located in membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) gene on spontaneous clearance of HBV and HCV infections and on liver fibro...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095921/ https://www.ncbi.nlm.nih.gov/pubmed/30116012 http://dx.doi.org/10.1038/s41598-018-30824-9 |
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author | Ezzikouri, Sayeh Elfihry, Raouia Chihab, Hajar Elmessaoudi-Idrissi, Mohcine Zaidane, Imane Jadid, Fatima Zahra Karami, Adnane Tahiri, Mohamed Elhabazi, Abdellah Kabine, Mostafa Chair, Mohammed Pineau, Pascal Benjelloun, Soumaya |
author_facet | Ezzikouri, Sayeh Elfihry, Raouia Chihab, Hajar Elmessaoudi-Idrissi, Mohcine Zaidane, Imane Jadid, Fatima Zahra Karami, Adnane Tahiri, Mohamed Elhabazi, Abdellah Kabine, Mostafa Chair, Mohammed Pineau, Pascal Benjelloun, Soumaya |
author_sort | Ezzikouri, Sayeh |
collection | PubMed |
description | The outcomes of HBV and HCV infections are associated both with viral and host genetic factors. Here, we explore the role of a genetic variation located in membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) gene on spontaneous clearance of HBV and HCV infections and on liver fibrosis. We genotyped MBOAT7 rs641738 polymorphism in 971 consecutive Moroccan subjects, including 288 patients with chronic hepatitis C (CHC), 98 cases with spontaneous clearance of HCV, 268 patients with chronic hepatitis B (CHB), 126 spontaneously cleared HBV infections and 191 healthy controls. MBOAT7 rs641738 variant is not associated with spontaneous clearance of HBV (OR = 0.67, 95% CI: 0.39–1.14; p = 0.131) and HCV infections (OR = 1.33, 95% CI: 0.79–2.23; p = 0.278). Furthermore, multivariable logistic regression analysis adjusted for biologically relevant covariates and potential confounders associated with the risk of liver disease progression revealed that MBOAT7 rs641738 is not associated either with fibrosis progression in CHC group (OR = 1.12; 95% CI: 0.55–2.28; p = 0.761) or with chronic progressive state in CHB patients (OR = 0.81; 95% CI: 0.41–1.61; p = 0.547). We conclude that the variant MBOAT7 rs641738 genotype is not associated with spontaneous clearance of HBV and HCV infections or with the progression of liver disease in chronic hepatitis B or C in a genetic context of Mediterranean patients. |
format | Online Article Text |
id | pubmed-6095921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-60959212018-08-23 Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients Ezzikouri, Sayeh Elfihry, Raouia Chihab, Hajar Elmessaoudi-Idrissi, Mohcine Zaidane, Imane Jadid, Fatima Zahra Karami, Adnane Tahiri, Mohamed Elhabazi, Abdellah Kabine, Mostafa Chair, Mohammed Pineau, Pascal Benjelloun, Soumaya Sci Rep Article The outcomes of HBV and HCV infections are associated both with viral and host genetic factors. Here, we explore the role of a genetic variation located in membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) gene on spontaneous clearance of HBV and HCV infections and on liver fibrosis. We genotyped MBOAT7 rs641738 polymorphism in 971 consecutive Moroccan subjects, including 288 patients with chronic hepatitis C (CHC), 98 cases with spontaneous clearance of HCV, 268 patients with chronic hepatitis B (CHB), 126 spontaneously cleared HBV infections and 191 healthy controls. MBOAT7 rs641738 variant is not associated with spontaneous clearance of HBV (OR = 0.67, 95% CI: 0.39–1.14; p = 0.131) and HCV infections (OR = 1.33, 95% CI: 0.79–2.23; p = 0.278). Furthermore, multivariable logistic regression analysis adjusted for biologically relevant covariates and potential confounders associated with the risk of liver disease progression revealed that MBOAT7 rs641738 is not associated either with fibrosis progression in CHC group (OR = 1.12; 95% CI: 0.55–2.28; p = 0.761) or with chronic progressive state in CHB patients (OR = 0.81; 95% CI: 0.41–1.61; p = 0.547). We conclude that the variant MBOAT7 rs641738 genotype is not associated with spontaneous clearance of HBV and HCV infections or with the progression of liver disease in chronic hepatitis B or C in a genetic context of Mediterranean patients. Nature Publishing Group UK 2018-08-16 /pmc/articles/PMC6095921/ /pubmed/30116012 http://dx.doi.org/10.1038/s41598-018-30824-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ezzikouri, Sayeh Elfihry, Raouia Chihab, Hajar Elmessaoudi-Idrissi, Mohcine Zaidane, Imane Jadid, Fatima Zahra Karami, Adnane Tahiri, Mohamed Elhabazi, Abdellah Kabine, Mostafa Chair, Mohammed Pineau, Pascal Benjelloun, Soumaya Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients |
title | Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients |
title_full | Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients |
title_fullStr | Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients |
title_full_unstemmed | Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients |
title_short | Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients |
title_sort | effect of mboat7 variant on hepatitis b and c infections in moroccan patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095921/ https://www.ncbi.nlm.nih.gov/pubmed/30116012 http://dx.doi.org/10.1038/s41598-018-30824-9 |
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