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Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus

BACKGROUND: X-linked agammaglobulinemia (XLA) is a primary immunodeficiency caused by Bruton’s tyrosine kinase (BTK) mutation. Patients are susceptible to severe enterovirus infections. The underlying mechanism remains unknown. BTK is involved in toll-like receptors pathway, which initiates antivira...

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Detalles Bibliográficos
Autores principales:	Luk, Anderson Dik Wai, Ni, Ke, Wu, Yuet, Lam, Kwok-Tai, Chan, Koon-Wing, Lee, Pamela P., Tu, Wenwei, Mao, Huawei, Lau, Yu Lung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095995/ https://www.ncbi.nlm.nih.gov/pubmed/30147693 http://dx.doi.org/10.3389/fimmu.2018.01826

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