Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-signal Recognition Particle Antibody

A 72-year-old man was admitted due to dyspnea on exertion with interstitial shadows and elevated serum creatinine kinase (CK). Despite a close examination, which included magnetic resonance imaging (MRI), we could not diagnose myopathy. Prednisolone was administered and gradually tapered. One year l...

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Autores principales: Kusumoto, Tatsuya, Okamori, Satoshi, Masuzawa, Keita, Asakura, Takanori, Nishina, Naoshi, Chubachi, Shotaro, Naoki, Katsuhiko, Fukunaga, Koichi, Betsuyaku, Tomoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096015/
https://www.ncbi.nlm.nih.gov/pubmed/29491298
http://dx.doi.org/10.2169/internalmedicine.0303-17
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author Kusumoto, Tatsuya
Okamori, Satoshi
Masuzawa, Keita
Asakura, Takanori
Nishina, Naoshi
Chubachi, Shotaro
Naoki, Katsuhiko
Fukunaga, Koichi
Betsuyaku, Tomoko
author_facet Kusumoto, Tatsuya
Okamori, Satoshi
Masuzawa, Keita
Asakura, Takanori
Nishina, Naoshi
Chubachi, Shotaro
Naoki, Katsuhiko
Fukunaga, Koichi
Betsuyaku, Tomoko
author_sort Kusumoto, Tatsuya
collection PubMed
description A 72-year-old man was admitted due to dyspnea on exertion with interstitial shadows and elevated serum creatinine kinase (CK). Despite a close examination, which included magnetic resonance imaging (MRI), we could not diagnose myopathy. Prednisolone was administered and gradually tapered. One year later, anti-signal recognition particle (SRP) antibody was confirmed and he was re-admitted for hypoxemia with elevated CK. MRI revealed muscle edema and a histopathological examination of a muscle biopsy specimen showed necrotizing myopathy. Prednisolone, cyclosporine, and intravenous immunoglobulin were administered. Physicians should carefully monitor muscle symptoms and serum CK levels in cases of interstitial lung disease with anti-SRP antibodies.
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spelling pubmed-60960152018-08-17 Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-signal Recognition Particle Antibody Kusumoto, Tatsuya Okamori, Satoshi Masuzawa, Keita Asakura, Takanori Nishina, Naoshi Chubachi, Shotaro Naoki, Katsuhiko Fukunaga, Koichi Betsuyaku, Tomoko Intern Med Case Report A 72-year-old man was admitted due to dyspnea on exertion with interstitial shadows and elevated serum creatinine kinase (CK). Despite a close examination, which included magnetic resonance imaging (MRI), we could not diagnose myopathy. Prednisolone was administered and gradually tapered. One year later, anti-signal recognition particle (SRP) antibody was confirmed and he was re-admitted for hypoxemia with elevated CK. MRI revealed muscle edema and a histopathological examination of a muscle biopsy specimen showed necrotizing myopathy. Prednisolone, cyclosporine, and intravenous immunoglobulin were administered. Physicians should carefully monitor muscle symptoms and serum CK levels in cases of interstitial lung disease with anti-SRP antibodies. The Japanese Society of Internal Medicine 2018-02-28 2018-07-15 /pmc/articles/PMC6096015/ /pubmed/29491298 http://dx.doi.org/10.2169/internalmedicine.0303-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kusumoto, Tatsuya
Okamori, Satoshi
Masuzawa, Keita
Asakura, Takanori
Nishina, Naoshi
Chubachi, Shotaro
Naoki, Katsuhiko
Fukunaga, Koichi
Betsuyaku, Tomoko
Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-signal Recognition Particle Antibody
title Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-signal Recognition Particle Antibody
title_full Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-signal Recognition Particle Antibody
title_fullStr Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-signal Recognition Particle Antibody
title_full_unstemmed Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-signal Recognition Particle Antibody
title_short Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-signal Recognition Particle Antibody
title_sort development of necrotizing myopathy following interstitial lung disease with anti-signal recognition particle antibody
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096015/
https://www.ncbi.nlm.nih.gov/pubmed/29491298
http://dx.doi.org/10.2169/internalmedicine.0303-17
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