Efficacy of Oral Factor Xa Inhibitor for Venous Thromboembolism in a Patient with Antithrombin Deficiency

A 19-year-old man was referred due to sudden onset of right foot pain and chest discomfort. Contrast-enhanced computed tomography revealed massive thrombi in the right pulmonary artery and femoral vein. The patient's father had experienced multiple recurrences of venous thromboembolism (VTE) an...

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Autores principales: Minami, Kentaro, Kumagai, Koji, Sugai, Yoshinao, Nakamura, Kohki, Naito, Shigeto, Oshima, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096030/
https://www.ncbi.nlm.nih.gov/pubmed/29526957
http://dx.doi.org/10.2169/internalmedicine.0483-17
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author Minami, Kentaro
Kumagai, Koji
Sugai, Yoshinao
Nakamura, Kohki
Naito, Shigeto
Oshima, Shigeru
author_facet Minami, Kentaro
Kumagai, Koji
Sugai, Yoshinao
Nakamura, Kohki
Naito, Shigeto
Oshima, Shigeru
author_sort Minami, Kentaro
collection PubMed
description A 19-year-old man was referred due to sudden onset of right foot pain and chest discomfort. Contrast-enhanced computed tomography revealed massive thrombi in the right pulmonary artery and femoral vein. The patient's father had experienced multiple recurrences of venous thromboembolism (VTE) and was diagnosed with inherited antithrombin deficiency by a genetic examination. The patient was administered the oral factor Xa inhibitor rivaroxaban (30 mg). After seven days, the thrombus disappeared. Rivaroxaban (15 mg) was continued for 6 months with no recurrence, indicating the efficacy of this factor Xa inhibitor for the treatment and prevention of VTE in patients with antithrombin deficiency.
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spelling pubmed-60960302018-08-17 Efficacy of Oral Factor Xa Inhibitor for Venous Thromboembolism in a Patient with Antithrombin Deficiency Minami, Kentaro Kumagai, Koji Sugai, Yoshinao Nakamura, Kohki Naito, Shigeto Oshima, Shigeru Intern Med Case Report A 19-year-old man was referred due to sudden onset of right foot pain and chest discomfort. Contrast-enhanced computed tomography revealed massive thrombi in the right pulmonary artery and femoral vein. The patient's father had experienced multiple recurrences of venous thromboembolism (VTE) and was diagnosed with inherited antithrombin deficiency by a genetic examination. The patient was administered the oral factor Xa inhibitor rivaroxaban (30 mg). After seven days, the thrombus disappeared. Rivaroxaban (15 mg) was continued for 6 months with no recurrence, indicating the efficacy of this factor Xa inhibitor for the treatment and prevention of VTE in patients with antithrombin deficiency. The Japanese Society of Internal Medicine 2018-03-09 2018-07-15 /pmc/articles/PMC6096030/ /pubmed/29526957 http://dx.doi.org/10.2169/internalmedicine.0483-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Minami, Kentaro
Kumagai, Koji
Sugai, Yoshinao
Nakamura, Kohki
Naito, Shigeto
Oshima, Shigeru
Efficacy of Oral Factor Xa Inhibitor for Venous Thromboembolism in a Patient with Antithrombin Deficiency
title Efficacy of Oral Factor Xa Inhibitor for Venous Thromboembolism in a Patient with Antithrombin Deficiency
title_full Efficacy of Oral Factor Xa Inhibitor for Venous Thromboembolism in a Patient with Antithrombin Deficiency
title_fullStr Efficacy of Oral Factor Xa Inhibitor for Venous Thromboembolism in a Patient with Antithrombin Deficiency
title_full_unstemmed Efficacy of Oral Factor Xa Inhibitor for Venous Thromboembolism in a Patient with Antithrombin Deficiency
title_short Efficacy of Oral Factor Xa Inhibitor for Venous Thromboembolism in a Patient with Antithrombin Deficiency
title_sort efficacy of oral factor xa inhibitor for venous thromboembolism in a patient with antithrombin deficiency
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096030/
https://www.ncbi.nlm.nih.gov/pubmed/29526957
http://dx.doi.org/10.2169/internalmedicine.0483-17
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