In vivo acquired sorafenib-resistant patient-derived tumor model displays alternative angiogenic pathways, multi-drug resistance and chromosome instability

Acquired resistance to targeted therapies is an important clinical challenge. Research focusing on acquired resistance is hindered by the lack of relevant model systems. In the present study, the generation and characterization of an in vivo acquired sorafenib-resistant hepatocellular carcinoma (HCC...

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Detalles Bibliográficos
Autores principales: Hu, Gang, Zhang, Yixin, Ouyang, Kedong, Xie, Fubo, Fang, Houshun, Yang, Xueyang, Liu, Kunyan, Wang, Zongyu, Tang, Xuzhen, Liu, Jibin, Yang, Lei, Jiang, Zhenzhou, Tao, Weikang, Zhou, He, Zhang, Luyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096179/
https://www.ncbi.nlm.nih.gov/pubmed/30127946
http://dx.doi.org/10.3892/ol.2018.9078

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