NOTCH and Graft-Versus-Host Disease

In allogeneic hematopoietic stem cell transplantation, which is the major curative therapy for hematological malignancies, T cells play a key role in the development of graft-versus-host disease (GvHD). NOTCH pathway is a conserved signal transduction system that regulates T cell development and dif...

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Autores principales: Di Ianni, Mauro, Del Papa, Beatrice, Baldoni, Stefano, Di Tommaso, Ambra, Fabi, Bianca, Rosati, Emanuela, Natale, Annalisa, Santarone, Stella, Olioso, Paola, Papalinetti, Gabriele, Giancola, Raffaella, Accorsi, Patrizia, Di Bartolomeo, Paolo, Sportoletti, Paolo, Falzetti, Franca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096230/
https://www.ncbi.nlm.nih.gov/pubmed/30147692
http://dx.doi.org/10.3389/fimmu.2018.01825
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author Di Ianni, Mauro
Del Papa, Beatrice
Baldoni, Stefano
Di Tommaso, Ambra
Fabi, Bianca
Rosati, Emanuela
Natale, Annalisa
Santarone, Stella
Olioso, Paola
Papalinetti, Gabriele
Giancola, Raffaella
Accorsi, Patrizia
Di Bartolomeo, Paolo
Sportoletti, Paolo
Falzetti, Franca
author_facet Di Ianni, Mauro
Del Papa, Beatrice
Baldoni, Stefano
Di Tommaso, Ambra
Fabi, Bianca
Rosati, Emanuela
Natale, Annalisa
Santarone, Stella
Olioso, Paola
Papalinetti, Gabriele
Giancola, Raffaella
Accorsi, Patrizia
Di Bartolomeo, Paolo
Sportoletti, Paolo
Falzetti, Franca
author_sort Di Ianni, Mauro
collection PubMed
description In allogeneic hematopoietic stem cell transplantation, which is the major curative therapy for hematological malignancies, T cells play a key role in the development of graft-versus-host disease (GvHD). NOTCH pathway is a conserved signal transduction system that regulates T cell development and differentiation. The present review analyses the role of the NOTCH signaling as a new regulator of acute GvHD. NOTCH signaling could also represent a new therapeutic target for GvHD.
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spelling pubmed-60962302018-08-24 NOTCH and Graft-Versus-Host Disease Di Ianni, Mauro Del Papa, Beatrice Baldoni, Stefano Di Tommaso, Ambra Fabi, Bianca Rosati, Emanuela Natale, Annalisa Santarone, Stella Olioso, Paola Papalinetti, Gabriele Giancola, Raffaella Accorsi, Patrizia Di Bartolomeo, Paolo Sportoletti, Paolo Falzetti, Franca Front Immunol Immunology In allogeneic hematopoietic stem cell transplantation, which is the major curative therapy for hematological malignancies, T cells play a key role in the development of graft-versus-host disease (GvHD). NOTCH pathway is a conserved signal transduction system that regulates T cell development and differentiation. The present review analyses the role of the NOTCH signaling as a new regulator of acute GvHD. NOTCH signaling could also represent a new therapeutic target for GvHD. Frontiers Media S.A. 2018-08-10 /pmc/articles/PMC6096230/ /pubmed/30147692 http://dx.doi.org/10.3389/fimmu.2018.01825 Text en Copyright © 2018 Di Ianni, Del Papa, Baldoni, Di Tommaso, Fabi, Rosati, Natale, Santarone, Olioso, Papalinetti, Giancola, Accorsi, Di Bartolomeo, Sportoletti and Falzetti. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Di Ianni, Mauro
Del Papa, Beatrice
Baldoni, Stefano
Di Tommaso, Ambra
Fabi, Bianca
Rosati, Emanuela
Natale, Annalisa
Santarone, Stella
Olioso, Paola
Papalinetti, Gabriele
Giancola, Raffaella
Accorsi, Patrizia
Di Bartolomeo, Paolo
Sportoletti, Paolo
Falzetti, Franca
NOTCH and Graft-Versus-Host Disease
title NOTCH and Graft-Versus-Host Disease
title_full NOTCH and Graft-Versus-Host Disease
title_fullStr NOTCH and Graft-Versus-Host Disease
title_full_unstemmed NOTCH and Graft-Versus-Host Disease
title_short NOTCH and Graft-Versus-Host Disease
title_sort notch and graft-versus-host disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096230/
https://www.ncbi.nlm.nih.gov/pubmed/30147692
http://dx.doi.org/10.3389/fimmu.2018.01825
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