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Neoangiogenesis of gastric submucosa-invasive adenocarcinoma

Early gastric cancer may be defined as mucosal or submucosal invasive carcinoma, and exhibits a good prognosis: 90% of patients survive >10 years. Early gastric cancer infrequently exhibits lymph node metastasis, although submucosal invasion, the presence of vascular invasion and/or lymphatic per...

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Autores principales: Sasaki, Hanae, Morohashi, Satoko, Toba, Takahito, Seino, Hiroko, Yoshizawa, Tadashi, Hirai, Hideaki, Haga, Toshihiro, Wu, Yunyan, Kijima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096252/
https://www.ncbi.nlm.nih.gov/pubmed/30128004
http://dx.doi.org/10.3892/ol.2018.9116
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author Sasaki, Hanae
Morohashi, Satoko
Toba, Takahito
Seino, Hiroko
Yoshizawa, Tadashi
Hirai, Hideaki
Haga, Toshihiro
Wu, Yunyan
Kijima, Hiroshi
author_facet Sasaki, Hanae
Morohashi, Satoko
Toba, Takahito
Seino, Hiroko
Yoshizawa, Tadashi
Hirai, Hideaki
Haga, Toshihiro
Wu, Yunyan
Kijima, Hiroshi
author_sort Sasaki, Hanae
collection PubMed
description Early gastric cancer may be defined as mucosal or submucosal invasive carcinoma, and exhibits a good prognosis: 90% of patients survive >10 years. Early gastric cancer infrequently exhibits lymph node metastasis, although submucosal invasion, the presence of vascular invasion and/or lymphatic permeation are independent risk factors for lymph node metastasis in early gastric cancer. The analysis of tumor lymphangiogenesis and angiogenesis are important to determine the extent of invasive progression and metastasis in patients. Previously, the presence of vessels expressing the D2-40 antibody and the factor-VIII protein has been identified immunohistochemically. The vessels that are immunoreactive for D2-40 and factor-VIII are morphologically similar to lymphatic vessels or small-size veins, also termed venules. In the present study, the association between tumor invasion and neoangiogenesis in early gastric cancer was examined. The D2-40/factor-VIII double-stained vessel (DSV) density was analyzed, in addition to lymphatic and blood vessel (vein and artery) density, using 46 submucosa-invasive and 50 mucosal carcinomas, and 20 non-neoplastic gastric tissues. The lymphatic density and DSV density of submucosa beneath the carcinoma and submucosa of the surrounding region in submucosa-invasive carcinoma were significantly increased (P<0.001) in comparison with those in mucosal carcinoma or non-neoplastic gastric tissue. No significant difference was observed in blood vessel density between non-neoplastic gastric, mucosal carcinoma and submucosa-invasive carcinoma tissues other than that of mucosa. The present study suggests the potential for the presence of D2-40/factor-VIII DSV and the importance of this vessel for neoangiogenesis in early gastric cancer.
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spelling pubmed-60962522018-08-20 Neoangiogenesis of gastric submucosa-invasive adenocarcinoma Sasaki, Hanae Morohashi, Satoko Toba, Takahito Seino, Hiroko Yoshizawa, Tadashi Hirai, Hideaki Haga, Toshihiro Wu, Yunyan Kijima, Hiroshi Oncol Lett Articles Early gastric cancer may be defined as mucosal or submucosal invasive carcinoma, and exhibits a good prognosis: 90% of patients survive >10 years. Early gastric cancer infrequently exhibits lymph node metastasis, although submucosal invasion, the presence of vascular invasion and/or lymphatic permeation are independent risk factors for lymph node metastasis in early gastric cancer. The analysis of tumor lymphangiogenesis and angiogenesis are important to determine the extent of invasive progression and metastasis in patients. Previously, the presence of vessels expressing the D2-40 antibody and the factor-VIII protein has been identified immunohistochemically. The vessels that are immunoreactive for D2-40 and factor-VIII are morphologically similar to lymphatic vessels or small-size veins, also termed venules. In the present study, the association between tumor invasion and neoangiogenesis in early gastric cancer was examined. The D2-40/factor-VIII double-stained vessel (DSV) density was analyzed, in addition to lymphatic and blood vessel (vein and artery) density, using 46 submucosa-invasive and 50 mucosal carcinomas, and 20 non-neoplastic gastric tissues. The lymphatic density and DSV density of submucosa beneath the carcinoma and submucosa of the surrounding region in submucosa-invasive carcinoma were significantly increased (P<0.001) in comparison with those in mucosal carcinoma or non-neoplastic gastric tissue. No significant difference was observed in blood vessel density between non-neoplastic gastric, mucosal carcinoma and submucosa-invasive carcinoma tissues other than that of mucosa. The present study suggests the potential for the presence of D2-40/factor-VIII DSV and the importance of this vessel for neoangiogenesis in early gastric cancer. D.A. Spandidos 2018-09 2018-07-10 /pmc/articles/PMC6096252/ /pubmed/30128004 http://dx.doi.org/10.3892/ol.2018.9116 Text en Copyright: © Sasaki et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Sasaki, Hanae
Morohashi, Satoko
Toba, Takahito
Seino, Hiroko
Yoshizawa, Tadashi
Hirai, Hideaki
Haga, Toshihiro
Wu, Yunyan
Kijima, Hiroshi
Neoangiogenesis of gastric submucosa-invasive adenocarcinoma
title Neoangiogenesis of gastric submucosa-invasive adenocarcinoma
title_full Neoangiogenesis of gastric submucosa-invasive adenocarcinoma
title_fullStr Neoangiogenesis of gastric submucosa-invasive adenocarcinoma
title_full_unstemmed Neoangiogenesis of gastric submucosa-invasive adenocarcinoma
title_short Neoangiogenesis of gastric submucosa-invasive adenocarcinoma
title_sort neoangiogenesis of gastric submucosa-invasive adenocarcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096252/
https://www.ncbi.nlm.nih.gov/pubmed/30128004
http://dx.doi.org/10.3892/ol.2018.9116
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