The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma

Epstein-Barr virus (EBV) is an oncogenic herpes virus that is closely associated with the initiation and development of nasopharyngeal carcinoma (NPC), lymphoma and other malignant tumors. EBV encodes 44 mature miRNAs that regulate viral and host cell gene expression and plays a variety of roles in...

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Autores principales: Fan, Chunmei, Tang, Yanyan, Wang, Jinpeng, Xiong, Fang, Guo, Can, Wang, Yumin, Xiang, Bo, Zhou, Ming, Li, Xiayu, Wu, Xu, Li, Yong, Li, Xiaoling, Li, Guiyuan, Xiong, Wei, Zeng, Zhaoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096363/
https://www.ncbi.nlm.nih.gov/pubmed/30123354
http://dx.doi.org/10.7150/jca.25460
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author Fan, Chunmei
Tang, Yanyan
Wang, Jinpeng
Xiong, Fang
Guo, Can
Wang, Yumin
Xiang, Bo
Zhou, Ming
Li, Xiayu
Wu, Xu
Li, Yong
Li, Xiaoling
Li, Guiyuan
Xiong, Wei
Zeng, Zhaoyang
author_facet Fan, Chunmei
Tang, Yanyan
Wang, Jinpeng
Xiong, Fang
Guo, Can
Wang, Yumin
Xiang, Bo
Zhou, Ming
Li, Xiayu
Wu, Xu
Li, Yong
Li, Xiaoling
Li, Guiyuan
Xiong, Wei
Zeng, Zhaoyang
author_sort Fan, Chunmei
collection PubMed
description Epstein-Barr virus (EBV) is an oncogenic herpes virus that is closely associated with the initiation and development of nasopharyngeal carcinoma (NPC), lymphoma and other malignant tumors. EBV encodes 44 mature miRNAs that regulate viral and host cell gene expression and plays a variety of roles in biological functions and the development of cancer. In this review, we summarized the biological functions and molecular mechanisms of Epstein-Barr virus-encoded microRNAs (EBV miRNAs) in tumor immune evasion, proliferation, anti-apoptosis, invasion, metastasis and as a potential biomarker for NPC diagnosis and prognosis. The knowledge generated by EBV miRNAs can be used for EBV miRNA-based precision cancer treatments in the near future.
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spelling pubmed-60963632018-08-17 The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma Fan, Chunmei Tang, Yanyan Wang, Jinpeng Xiong, Fang Guo, Can Wang, Yumin Xiang, Bo Zhou, Ming Li, Xiayu Wu, Xu Li, Yong Li, Xiaoling Li, Guiyuan Xiong, Wei Zeng, Zhaoyang J Cancer Review Epstein-Barr virus (EBV) is an oncogenic herpes virus that is closely associated with the initiation and development of nasopharyngeal carcinoma (NPC), lymphoma and other malignant tumors. EBV encodes 44 mature miRNAs that regulate viral and host cell gene expression and plays a variety of roles in biological functions and the development of cancer. In this review, we summarized the biological functions and molecular mechanisms of Epstein-Barr virus-encoded microRNAs (EBV miRNAs) in tumor immune evasion, proliferation, anti-apoptosis, invasion, metastasis and as a potential biomarker for NPC diagnosis and prognosis. The knowledge generated by EBV miRNAs can be used for EBV miRNA-based precision cancer treatments in the near future. Ivyspring International Publisher 2018-07-30 /pmc/articles/PMC6096363/ /pubmed/30123354 http://dx.doi.org/10.7150/jca.25460 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Fan, Chunmei
Tang, Yanyan
Wang, Jinpeng
Xiong, Fang
Guo, Can
Wang, Yumin
Xiang, Bo
Zhou, Ming
Li, Xiayu
Wu, Xu
Li, Yong
Li, Xiaoling
Li, Guiyuan
Xiong, Wei
Zeng, Zhaoyang
The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma
title The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma
title_full The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma
title_fullStr The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma
title_full_unstemmed The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma
title_short The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma
title_sort emerging role of epstein-barr virus encoded micrornas in nasopharyngeal carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096363/
https://www.ncbi.nlm.nih.gov/pubmed/30123354
http://dx.doi.org/10.7150/jca.25460
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