Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer

Hotspot mutations of isocitrate dehydrogenase 1 and 2 (IDH1/2) have been studied in several cancers. However, the function of wild-type IDH2 in lung cancer and the mechanism of its contribution to growth of cancer cells remain unknown. Here, we explored the role and mechanism of wild-type IDH2 in pr...

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Detalles Bibliográficos
Autores principales: Li, Jiangjiang, He, Ya, Tan, Zheqiong, Lu, Jingchen, Li, Liling, Song, Xin, Shi, Feng, Xie, Longlong, You, Shuo, Luo, Xiangjian, Li, Namei, Li, Yueshuo, Liu, Xiaolan, Tang, Min, Weng, Xinxian, Yi, Wei, Fan, Jia, Zhou, Jian, Qiang, Gao, Qiu, ShuangJian, Wu, Weizhong, Bode, Ann M., Cao, Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096397/
https://www.ncbi.nlm.nih.gov/pubmed/30128035
http://dx.doi.org/10.7150/thno.21524

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