Clinical significance of CRNDE transcript variants in glioblastoma multiforme

The long non-coding RNA CRNDE is an oncogene that promotes tumor growth in glioblastoma multiforme (GBM). At least five CRNDE transcript variants with possibly different functional roles have been described in recent studies. Here, we report our preliminary findings on the differential expressions o...

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Detalles Bibliográficos
Autores principales: Kiang, Karrie M.Y., Leung, Gilberto K.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096424/
https://www.ncbi.nlm.nih.gov/pubmed/30159429
http://dx.doi.org/10.1016/j.ncrna.2017.07.001
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author Kiang, Karrie M.Y.
Leung, Gilberto K.K.
author_facet Kiang, Karrie M.Y.
Leung, Gilberto K.K.
author_sort Kiang, Karrie M.Y.
collection PubMed
description The long non-coding RNA CRNDE is an oncogene that promotes tumor growth in glioblastoma multiforme (GBM). At least five CRNDE transcript variants with possibly different functional roles have been described in recent studies. Here, we report our preliminary findings on the differential expressions of CRNDE transcript variants in GBM, and their prognostic significance. Our preliminary data suggest that different transcript variants of CRNDE might have different functions in GBM and should be further studied as potential biomarkers for clinical prognostication.
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spelling pubmed-60964242018-08-29 Clinical significance of CRNDE transcript variants in glioblastoma multiforme Kiang, Karrie M.Y. Leung, Gilberto K.K. Noncoding RNA Res Article The long non-coding RNA CRNDE is an oncogene that promotes tumor growth in glioblastoma multiforme (GBM). At least five CRNDE transcript variants with possibly different functional roles have been described in recent studies. Here, we report our preliminary findings on the differential expressions of CRNDE transcript variants in GBM, and their prognostic significance. Our preliminary data suggest that different transcript variants of CRNDE might have different functions in GBM and should be further studied as potential biomarkers for clinical prognostication. KeAi Publishing 2017-07-26 /pmc/articles/PMC6096424/ /pubmed/30159429 http://dx.doi.org/10.1016/j.ncrna.2017.07.001 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Kiang, Karrie M.Y.
Leung, Gilberto K.K.
Clinical significance of CRNDE transcript variants in glioblastoma multiforme
title Clinical significance of CRNDE transcript variants in glioblastoma multiforme
title_full Clinical significance of CRNDE transcript variants in glioblastoma multiforme
title_fullStr Clinical significance of CRNDE transcript variants in glioblastoma multiforme
title_full_unstemmed Clinical significance of CRNDE transcript variants in glioblastoma multiforme
title_short Clinical significance of CRNDE transcript variants in glioblastoma multiforme
title_sort clinical significance of crnde transcript variants in glioblastoma multiforme
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096424/
https://www.ncbi.nlm.nih.gov/pubmed/30159429
http://dx.doi.org/10.1016/j.ncrna.2017.07.001
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