Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons

Transactivating DNA-binding protein-43 (TDP-43) deposits represent a typical finding in almost all ALS patients, more than half of FTLD patients and patients with several other neurodegenerative disorders. It appears that perturbation of nucleo-cytoplasmic transport is an important event in these co...

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Detalles Bibliográficos
Autores principales: Svahn, Adam J., Don, Emily K., Badrock, Andrew P., Cole, Nicholas J., Graeber, Manuel B., Yerbury, Justin J., Chung, Roger, Morsch, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096729/
https://www.ncbi.nlm.nih.gov/pubmed/29943193
http://dx.doi.org/10.1007/s00401-018-1875-2

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