The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity

Parkinson’s disease is associated with intracellular α-synuclein accumulation and ventral midbrain dopaminergic neuronal death in the Substantia Nigra of brain patients. The Rho GTPase pathway, mainly linking surface receptors to the organization of the actin and microtubule cytoskeletons, has been...

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Detalles Bibliográficos
Autores principales: Kim, Hanna, Calatayud, Carles, Guha, Sanjib, Fernández-Carasa, Irene, Berkowitz, Laura, Carballo-Carbajal, Iria, Ezquerra, Mario, Fernández-Santiago, Rubén, Kapahi, Pankaj, Raya, Ángel, Miranda-Vizuete, Antonio, Lizcano, Jose Miguel, Vila, Miquel, Caldwell, Kim A., Caldwell, Guy A., Consiglio, Antonella, Dalfo, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096980/
https://www.ncbi.nlm.nih.gov/pubmed/29429047
http://dx.doi.org/10.1007/s12035-018-0881-7

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