Multimeric Amphipathic α‐Helical Sequences for Rapid and Efficient Intracellular Protein Transport at Nanomolar Concentrations

An amphipathic leucine (L) and lysine (K)‐rich α‐helical peptide is multimerized based on helix‐loop‐helix structures to maximize the penetrating activities. The multimeric LK‐based cell penetrating peptides (LK‐CPPs) can penetrate cells as protein‐fused forms at 100–1000‐fold lower concentrations t...

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Detalles Bibliográficos
Autores principales: Oh, Jae Hoon, Chong, Seung‐Eun, Nam, Sohee, Hyun, Soonsil, Choi, Sejong, Gye, Hyojun, Jang, Sangmok, Jang, Joomyung, Hwang, Sung Won, Yu, Jaehoon, Lee, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096998/
https://www.ncbi.nlm.nih.gov/pubmed/30128238
http://dx.doi.org/10.1002/advs.201800240

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