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Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis

Covering: up to 2017 2-Oxoglutarate (2OG) dependent oxygenases and the homologous oxidase isopenicillin N synthase (IPNS) play crucial roles in the biosynthesis of β-lactam ring containing natural products. IPNS catalyses formation of the bicyclic penicillin nucleus from a tripeptide. 2OG oxygenases...

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Detalles Bibliográficos
Autores principales:	Rabe, Patrick, Kamps, Jos J. A. G., Schofield, Christopher J., Lohans, Christopher T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097109/ https://www.ncbi.nlm.nih.gov/pubmed/29808887 http://dx.doi.org/10.1039/c8np00002f

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