Simultaneous detection of lung fusions using a multiplex RT-PCR next generation sequencing-based approach: a multi-institutional research study

BACKGROUND: Gene fusion events resulting from chromosomal rearrangements play an important role in initiation of lung adenocarcinoma. The recent association of four oncogenic driver genes, ALK, ROS1, RET, and NTRK1, as lung tumor predictive biomarkers has increased the need for development of up-to-...

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Detalles Bibliográficos
Autores principales: Vaughn, Cecily P., Costa, José Luis, Feilotter, Harriet E., Petraroli, Rosella, Bagai, Varun, Rachiglio, Anna Maria, Marino, Federica Zito, Tops, Bastiaan, Kurth, Henriette M., Sakai, Kazuko, Mafficini, Andrea, Bastien, Roy R. L., Reiman, Anne, Le Corre, Delphine, Boag, Alexander, Crocker, Susan, Bihl, Michel, Hirschmann, Astrid, Scarpa, Aldo, Machado, José Carlos, Blons, Hélène, Sheils, Orla, Bramlett, Kelli, Ligtenberg, Marjolijn J. L., Cree, Ian A., Normanno, Nicola, Nishio, Kazuto, Laurent-Puig, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097211/
https://www.ncbi.nlm.nih.gov/pubmed/30115026
http://dx.doi.org/10.1186/s12885-018-4736-4

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