Pathogenic Signal Sequence Mutations in Progranulin Disrupt SRP Interactions Required for mRNA Stability

Cells have evolved quality control pathways to prevent the accumulation of improperly localized proteins, which are often toxic. One of these pathways, regulation of aberrant protein production (RAPP), recognizes aberrant secretory proteins during translation and degrades the associated mRNA. Here,...

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Detalles Bibliográficos
Autores principales: Pinarbasi, Emile S., Karamyshev, Andrey L., Tikhonova, Elena B., Wu, I-Hui, Hudson, Henry, Thomas, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097231/
https://www.ncbi.nlm.nih.gov/pubmed/29874572
http://dx.doi.org/10.1016/j.celrep.2018.05.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097231/
https://www.ncbi.nlm.nih.gov/pubmed/29874572
http://dx.doi.org/10.1016/j.celrep.2018.05.003

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