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Correlation between CCL4 gene polymorphisms and clinical aspects of breast cancer

Breast cancer is a major cause of cancer mortality amongst women. Chemokine (C-C motif) ligand 4 is encoded by the CCL4 gene; specific CCL4 gene polymorphisms are related to the risks and prognoses of various diseases. In this study, we examined whether CCL4 gene single nucleotide polymorphisms (SNP...

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Autores principales: Hu, Gui-Nv, Tzeng, Huey-En, Chen, Po-Chun, Wang, Chao-Qun, Zhao, Yong-Ming, Wang, Yan, Su, Chen-Ming, Tang, Chih-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097259/
https://www.ncbi.nlm.nih.gov/pubmed/30123055
http://dx.doi.org/10.7150/ijms.26771
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author Hu, Gui-Nv
Tzeng, Huey-En
Chen, Po-Chun
Wang, Chao-Qun
Zhao, Yong-Ming
Wang, Yan
Su, Chen-Ming
Tang, Chih-Hsin
author_facet Hu, Gui-Nv
Tzeng, Huey-En
Chen, Po-Chun
Wang, Chao-Qun
Zhao, Yong-Ming
Wang, Yan
Su, Chen-Ming
Tang, Chih-Hsin
author_sort Hu, Gui-Nv
collection PubMed
description Breast cancer is a major cause of cancer mortality amongst women. Chemokine (C-C motif) ligand 4 is encoded by the CCL4 gene; specific CCL4 gene polymorphisms are related to the risks and prognoses of various diseases. In this study, we examined whether CCL4 gene single nucleotide polymorphisms (SNPs) predict the risk and progression of breast cancer. Between 2014 and 2016, we recruited 314 patients diagnosed with breast cancer and a cohort of 209 healthy participants (controls) without a history of cancer. Genotyping of the CCL4 rs1634507, rs10491121 and rs1719153 SNPs revealed no significant between-group differences for these polymorphisms. However, amongst luminal A and luminal B subtypes, compared with patients with the AA genotype, those carrying the AG genotype at SNP rs10491121 were less likely to develop lymph node metastasis. In addition, compared with AA carriers, those carrying the AG + GG genotype at SNP rs10491121 were at lower risk of developing distant metastasis, while the presence of the AT genotype at SNP rs1719153 increased the likelihood of pathologic grade (G3 or G4) disease. Variations in the CCL4 gene may help to predict breast cancer progression and metastasis.
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spelling pubmed-60972592018-08-17 Correlation between CCL4 gene polymorphisms and clinical aspects of breast cancer Hu, Gui-Nv Tzeng, Huey-En Chen, Po-Chun Wang, Chao-Qun Zhao, Yong-Ming Wang, Yan Su, Chen-Ming Tang, Chih-Hsin Int J Med Sci Research Paper Breast cancer is a major cause of cancer mortality amongst women. Chemokine (C-C motif) ligand 4 is encoded by the CCL4 gene; specific CCL4 gene polymorphisms are related to the risks and prognoses of various diseases. In this study, we examined whether CCL4 gene single nucleotide polymorphisms (SNPs) predict the risk and progression of breast cancer. Between 2014 and 2016, we recruited 314 patients diagnosed with breast cancer and a cohort of 209 healthy participants (controls) without a history of cancer. Genotyping of the CCL4 rs1634507, rs10491121 and rs1719153 SNPs revealed no significant between-group differences for these polymorphisms. However, amongst luminal A and luminal B subtypes, compared with patients with the AA genotype, those carrying the AG genotype at SNP rs10491121 were less likely to develop lymph node metastasis. In addition, compared with AA carriers, those carrying the AG + GG genotype at SNP rs10491121 were at lower risk of developing distant metastasis, while the presence of the AT genotype at SNP rs1719153 increased the likelihood of pathologic grade (G3 or G4) disease. Variations in the CCL4 gene may help to predict breast cancer progression and metastasis. Ivyspring International Publisher 2018-07-30 /pmc/articles/PMC6097259/ /pubmed/30123055 http://dx.doi.org/10.7150/ijms.26771 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Hu, Gui-Nv
Tzeng, Huey-En
Chen, Po-Chun
Wang, Chao-Qun
Zhao, Yong-Ming
Wang, Yan
Su, Chen-Ming
Tang, Chih-Hsin
Correlation between CCL4 gene polymorphisms and clinical aspects of breast cancer
title Correlation between CCL4 gene polymorphisms and clinical aspects of breast cancer
title_full Correlation between CCL4 gene polymorphisms and clinical aspects of breast cancer
title_fullStr Correlation between CCL4 gene polymorphisms and clinical aspects of breast cancer
title_full_unstemmed Correlation between CCL4 gene polymorphisms and clinical aspects of breast cancer
title_short Correlation between CCL4 gene polymorphisms and clinical aspects of breast cancer
title_sort correlation between ccl4 gene polymorphisms and clinical aspects of breast cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097259/
https://www.ncbi.nlm.nih.gov/pubmed/30123055
http://dx.doi.org/10.7150/ijms.26771
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