Cargando…
Association of osteoarthritis and circulating adiponectin levels: a systematic review and meta-analysis
BACKGROUND: The objective of this study was to perform a meta-analysis to investigate the specific relationship between the expression level of circulating adiponectin and osteoarthritis (OA). METHOD: Multiple databases were searched to estimate the high quality of studies relevant to adiponectin an...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097292/ https://www.ncbi.nlm.nih.gov/pubmed/30115130 http://dx.doi.org/10.1186/s12944-018-0838-x |
_version_ | 1783348272510795776 |
---|---|
author | Tang, Qian Hu, Zhi-Chao Shen, Li-Yan Shang, Ping Xu, Hua-Zi Liu, Hai-Xiao |
author_facet | Tang, Qian Hu, Zhi-Chao Shen, Li-Yan Shang, Ping Xu, Hua-Zi Liu, Hai-Xiao |
author_sort | Tang, Qian |
collection | PubMed |
description | BACKGROUND: The objective of this study was to perform a meta-analysis to investigate the specific relationship between the expression level of circulating adiponectin and osteoarthritis (OA). METHOD: Multiple databases were searched to estimate the high quality of studies relevant to adiponectin and OA. We extracted the data from the eligible studies and included them in the meta-analysis using a random effects model. Subgroup analysis and meta-regression were further performed to explore the potential sources of heterogeneity. RESULTS: Ten articles consisting of thirteen case-control studies that contained a combined total of 1255 subjects. Our results revealed that the OA patients displayed higher adiponectin levels than the healthy controls (SMD = 0.327, 95% CI: 0.11–0.55, P = 0.003). The ethnicity-stratified subgroup analysis indicated that the adiponectin was a sensitive biomarker in both Caucasians (P = 0.021) and Asians (P = 0.037). Moreover, the meta-regression analysis suggested that the sample size (P = 0.03) and nationality (p = 0.01) could account for a part of heterogeneity in our study. CONCLUSION: Taken together, the current study indicated that the adiponectin expression levels were higher in the OA patients than in the healthy controls and might be associated with OA prevalence. |
format | Online Article Text |
id | pubmed-6097292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60972922018-08-20 Association of osteoarthritis and circulating adiponectin levels: a systematic review and meta-analysis Tang, Qian Hu, Zhi-Chao Shen, Li-Yan Shang, Ping Xu, Hua-Zi Liu, Hai-Xiao Lipids Health Dis Review BACKGROUND: The objective of this study was to perform a meta-analysis to investigate the specific relationship between the expression level of circulating adiponectin and osteoarthritis (OA). METHOD: Multiple databases were searched to estimate the high quality of studies relevant to adiponectin and OA. We extracted the data from the eligible studies and included them in the meta-analysis using a random effects model. Subgroup analysis and meta-regression were further performed to explore the potential sources of heterogeneity. RESULTS: Ten articles consisting of thirteen case-control studies that contained a combined total of 1255 subjects. Our results revealed that the OA patients displayed higher adiponectin levels than the healthy controls (SMD = 0.327, 95% CI: 0.11–0.55, P = 0.003). The ethnicity-stratified subgroup analysis indicated that the adiponectin was a sensitive biomarker in both Caucasians (P = 0.021) and Asians (P = 0.037). Moreover, the meta-regression analysis suggested that the sample size (P = 0.03) and nationality (p = 0.01) could account for a part of heterogeneity in our study. CONCLUSION: Taken together, the current study indicated that the adiponectin expression levels were higher in the OA patients than in the healthy controls and might be associated with OA prevalence. BioMed Central 2018-08-16 /pmc/articles/PMC6097292/ /pubmed/30115130 http://dx.doi.org/10.1186/s12944-018-0838-x Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Tang, Qian Hu, Zhi-Chao Shen, Li-Yan Shang, Ping Xu, Hua-Zi Liu, Hai-Xiao Association of osteoarthritis and circulating adiponectin levels: a systematic review and meta-analysis |
title | Association of osteoarthritis and circulating adiponectin levels: a systematic review and meta-analysis |
title_full | Association of osteoarthritis and circulating adiponectin levels: a systematic review and meta-analysis |
title_fullStr | Association of osteoarthritis and circulating adiponectin levels: a systematic review and meta-analysis |
title_full_unstemmed | Association of osteoarthritis and circulating adiponectin levels: a systematic review and meta-analysis |
title_short | Association of osteoarthritis and circulating adiponectin levels: a systematic review and meta-analysis |
title_sort | association of osteoarthritis and circulating adiponectin levels: a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097292/ https://www.ncbi.nlm.nih.gov/pubmed/30115130 http://dx.doi.org/10.1186/s12944-018-0838-x |
work_keys_str_mv | AT tangqian associationofosteoarthritisandcirculatingadiponectinlevelsasystematicreviewandmetaanalysis AT huzhichao associationofosteoarthritisandcirculatingadiponectinlevelsasystematicreviewandmetaanalysis AT shenliyan associationofosteoarthritisandcirculatingadiponectinlevelsasystematicreviewandmetaanalysis AT shangping associationofosteoarthritisandcirculatingadiponectinlevelsasystematicreviewandmetaanalysis AT xuhuazi associationofosteoarthritisandcirculatingadiponectinlevelsasystematicreviewandmetaanalysis AT liuhaixiao associationofosteoarthritisandcirculatingadiponectinlevelsasystematicreviewandmetaanalysis |