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Visceral, general, abdominal adiposity and atherogenic index of plasma in relatively lean hemodialysis patients
BACKGROUND: Obesity is a well-established risk factor for atherosclerosis. However, it is unknown which measure of adiposity best relates to atherosclerosis in relatively lean maintenance hemodialysis (MHD) patients. We aimed to explore and compare the associations between different adiposity indice...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097306/ https://www.ncbi.nlm.nih.gov/pubmed/30115010 http://dx.doi.org/10.1186/s12882-018-0996-0 |
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author | Zhou, Chaomin Peng, Hongying Yuan, Jing Lin, Xin Zha, Yan Chen, Hui |
author_facet | Zhou, Chaomin Peng, Hongying Yuan, Jing Lin, Xin Zha, Yan Chen, Hui |
author_sort | Zhou, Chaomin |
collection | PubMed |
description | BACKGROUND: Obesity is a well-established risk factor for atherosclerosis. However, it is unknown which measure of adiposity best relates to atherosclerosis in relatively lean maintenance hemodialysis (MHD) patients. We aimed to explore and compare the associations between different adiposity indices reflecting general, abdominal, visceral adiposity and arteriosclerosis risk with atherogenic index of plasma(AIP) in relatively lean MHD patients. METHODS: We conducted a multicenter, cross-sectional study in Guizhou Province, Southwest China. General/abdominal adiposity indices like body mass index (BMI), waist circumference(WC), waist-height ratio(WHtR), conicity index (Ci) and visceral obesity indices including visceral adiposity index (VAI), lipid accumulation product (LAP) and the hypertriglyceridemic waist phenotype (HW phenotype) were recorded. Univariate and multivariate linear regression models were used. RESULTS: All adiposity indices correlated positively with AIP in univariate analysis both in men and women except for Ci. After adjustment for age and traditional atherosclerosis risk factors, BMI, WC, WHtR, VAI and LAP still had associations with AIP both in men (β = 0.265, 0.153, 0.16, 0.788 and 0.74, respectively, all P < 0.001) and women (β = 0.34,0.199, 0.21, 0.83 and 0.74, respectively, all P < 0.001). After further adjustment for BMI, associations between AIP and VAI, LAP remained significant, but associations between WC, WHtR and AIP disappeared. CONCLUSIONS: The HW phenotype, VAI, and LAP, validated and convenient markers of visceral obesity, were superior to classical anthropometric general/ abdominal adiposity indices for atherosclerosis risk assessment, especially in relatively lean MHD patients aged 40 years or older. |
format | Online Article Text |
id | pubmed-6097306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60973062018-08-20 Visceral, general, abdominal adiposity and atherogenic index of plasma in relatively lean hemodialysis patients Zhou, Chaomin Peng, Hongying Yuan, Jing Lin, Xin Zha, Yan Chen, Hui BMC Nephrol Research Article BACKGROUND: Obesity is a well-established risk factor for atherosclerosis. However, it is unknown which measure of adiposity best relates to atherosclerosis in relatively lean maintenance hemodialysis (MHD) patients. We aimed to explore and compare the associations between different adiposity indices reflecting general, abdominal, visceral adiposity and arteriosclerosis risk with atherogenic index of plasma(AIP) in relatively lean MHD patients. METHODS: We conducted a multicenter, cross-sectional study in Guizhou Province, Southwest China. General/abdominal adiposity indices like body mass index (BMI), waist circumference(WC), waist-height ratio(WHtR), conicity index (Ci) and visceral obesity indices including visceral adiposity index (VAI), lipid accumulation product (LAP) and the hypertriglyceridemic waist phenotype (HW phenotype) were recorded. Univariate and multivariate linear regression models were used. RESULTS: All adiposity indices correlated positively with AIP in univariate analysis both in men and women except for Ci. After adjustment for age and traditional atherosclerosis risk factors, BMI, WC, WHtR, VAI and LAP still had associations with AIP both in men (β = 0.265, 0.153, 0.16, 0.788 and 0.74, respectively, all P < 0.001) and women (β = 0.34,0.199, 0.21, 0.83 and 0.74, respectively, all P < 0.001). After further adjustment for BMI, associations between AIP and VAI, LAP remained significant, but associations between WC, WHtR and AIP disappeared. CONCLUSIONS: The HW phenotype, VAI, and LAP, validated and convenient markers of visceral obesity, were superior to classical anthropometric general/ abdominal adiposity indices for atherosclerosis risk assessment, especially in relatively lean MHD patients aged 40 years or older. BioMed Central 2018-08-16 /pmc/articles/PMC6097306/ /pubmed/30115010 http://dx.doi.org/10.1186/s12882-018-0996-0 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Zhou, Chaomin Peng, Hongying Yuan, Jing Lin, Xin Zha, Yan Chen, Hui Visceral, general, abdominal adiposity and atherogenic index of plasma in relatively lean hemodialysis patients |
title | Visceral, general, abdominal adiposity and atherogenic index of plasma in relatively lean hemodialysis patients |
title_full | Visceral, general, abdominal adiposity and atherogenic index of plasma in relatively lean hemodialysis patients |
title_fullStr | Visceral, general, abdominal adiposity and atherogenic index of plasma in relatively lean hemodialysis patients |
title_full_unstemmed | Visceral, general, abdominal adiposity and atherogenic index of plasma in relatively lean hemodialysis patients |
title_short | Visceral, general, abdominal adiposity and atherogenic index of plasma in relatively lean hemodialysis patients |
title_sort | visceral, general, abdominal adiposity and atherogenic index of plasma in relatively lean hemodialysis patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097306/ https://www.ncbi.nlm.nih.gov/pubmed/30115010 http://dx.doi.org/10.1186/s12882-018-0996-0 |
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