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Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence
BACKGROUND: Functional characterization of non-coding elements in the human genome is a major genomic challenge and the maturation of genome-editing technologies is revolutionizing our ability to achieve this task. Oncogene-induced senescence, a cellular state of irreversible proliferation arrest th...
Autores principales: | Han, Ruiqi, Li, Li, Ugalde, Alejandro Piñeiro, Tal, Arieh, Manber, Zohar, Barbera, Eric Pinto, Chiara, Veronica Della, Elkon, Ran, Agami, Reuven |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097335/ https://www.ncbi.nlm.nih.gov/pubmed/30119690 http://dx.doi.org/10.1186/s13059-018-1494-1 |
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