Topiramate versus naltrexone for alcohol use disorder: study protocol for a genotype-stratified, double-blind randomised controlled trial (TOP study)

BACKGROUND: Current treatments for alcohol use disorders have limited efficacy and there is a high degree of variability in treatment response. In a randomised, placebo-controlled clinical trial, there was a large effect size for topiramate in people homozygous for the GRIK1 rs2832407*C allele. The...

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Detalles Bibliográficos
Autores principales: Morley, Kirsten C., Kranzler, Henry R., Luquin, Natasha, Baillie, Andrew, Shanahan, Marian, Trent, Ronald, Teesson, Maree, Haber, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097336/
https://www.ncbi.nlm.nih.gov/pubmed/30115121
http://dx.doi.org/10.1186/s13063-018-2824-z

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