Crystal structures of a llama VHH antibody BCD090-M2 targeting human ErbB3 receptor

Background: The ability of ErbB3 receptor to functionally complement ErbB1-2 and induce tumor resistance to their inhibitors makes it a unique target in cancer therapy by monoclonal antibodies. Here we report the expression, purification and structural analysis of a new anti-ErbB3 single-chain antib...

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Detalles Bibliográficos
Autores principales: Eliseev, Igor E., Yudenko, Anna N., Vysochinskaya, Vera V., Svirina, Anna A., Evstratyeva, Anna V., Drozhzhachih, Maria S., Krendeleva, Elena A., Vladimirova, Anna K., Nemankin, Timofey A., Ekimova, Viktoria M., Ulitin, Andrey B., Lomovskaya, Maria I., Yakovlev, Pavel A., Bukatin, Anton S., Knyazev, Nickolay A., Moiseenko, Fedor V., Chakchir, Oleg B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097396/
https://www.ncbi.nlm.nih.gov/pubmed/30430004
http://dx.doi.org/10.12688/f1000research.13612.2

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