Histidine-rich glycoprotein as an excellent biomarker for sepsis and beyond

Sepsis remains a critical problem with high morbidity and mortality worldwide. One of the problems we have in critical care is the need to find a good biomarker of sepsis to determine the existence of bacterial infection and the severity of patients. This would enable us to start appropriate treatme...

Descripción completa

Detalles Bibliográficos
Autores principales: Nishibori, Masahiro, Wake, Hidenori, Morimatsu, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097411/
https://www.ncbi.nlm.nih.gov/pubmed/30119699
http://dx.doi.org/10.1186/s13054-018-2127-5
_version_ 1783348298016358400
author Nishibori, Masahiro
Wake, Hidenori
Morimatsu, Hiroshi
author_facet Nishibori, Masahiro
Wake, Hidenori
Morimatsu, Hiroshi
author_sort Nishibori, Masahiro
collection PubMed
description Sepsis remains a critical problem with high morbidity and mortality worldwide. One of the problems we have in critical care is the need to find a good biomarker of sepsis to determine the existence of bacterial infection and the severity of patients. This would enable us to start appropriate treatment at an earlier stage of the disease course. We propose that decreases in the plasma protein histidine-rich glycoprotein (HRG) is an excellent biomarker of sepsis compared with the current markers. Based on the novel pathophysiological roles of HRG in the cascade of events during sepsis, we also discuss the potential for supplemental therapy with purified HRG.
format Online
Article
Text
id pubmed-6097411
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-60974112018-08-20 Histidine-rich glycoprotein as an excellent biomarker for sepsis and beyond Nishibori, Masahiro Wake, Hidenori Morimatsu, Hiroshi Crit Care Editorial Sepsis remains a critical problem with high morbidity and mortality worldwide. One of the problems we have in critical care is the need to find a good biomarker of sepsis to determine the existence of bacterial infection and the severity of patients. This would enable us to start appropriate treatment at an earlier stage of the disease course. We propose that decreases in the plasma protein histidine-rich glycoprotein (HRG) is an excellent biomarker of sepsis compared with the current markers. Based on the novel pathophysiological roles of HRG in the cascade of events during sepsis, we also discuss the potential for supplemental therapy with purified HRG. BioMed Central 2018-08-17 /pmc/articles/PMC6097411/ /pubmed/30119699 http://dx.doi.org/10.1186/s13054-018-2127-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Editorial
Nishibori, Masahiro
Wake, Hidenori
Morimatsu, Hiroshi
Histidine-rich glycoprotein as an excellent biomarker for sepsis and beyond
title Histidine-rich glycoprotein as an excellent biomarker for sepsis and beyond
title_full Histidine-rich glycoprotein as an excellent biomarker for sepsis and beyond
title_fullStr Histidine-rich glycoprotein as an excellent biomarker for sepsis and beyond
title_full_unstemmed Histidine-rich glycoprotein as an excellent biomarker for sepsis and beyond
title_short Histidine-rich glycoprotein as an excellent biomarker for sepsis and beyond
title_sort histidine-rich glycoprotein as an excellent biomarker for sepsis and beyond
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097411/
https://www.ncbi.nlm.nih.gov/pubmed/30119699
http://dx.doi.org/10.1186/s13054-018-2127-5
work_keys_str_mv AT nishiborimasahiro histidinerichglycoproteinasanexcellentbiomarkerforsepsisandbeyond
AT wakehidenori histidinerichglycoproteinasanexcellentbiomarkerforsepsisandbeyond
AT morimatsuhiroshi histidinerichglycoproteinasanexcellentbiomarkerforsepsisandbeyond

Ejemplares similares