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Targeting the Tie2–α(v)β(3) integrin axis with bi-specific reagents for the inhibition of angiogenesis
BACKGROUND: Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activation of integrins by Tie2, rendering the Ang/Tie2/integrin axis an attractive...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097439/ https://www.ncbi.nlm.nih.gov/pubmed/30119679 http://dx.doi.org/10.1186/s12915-018-0557-9 |