Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking

Cholesterol plays a key role in membrane protein function and signaling in endothelial cells. Thus, disturbing cholesterol trafficking is an effective approach for inhibiting angiogenesis. We recently identified astemizole (AST), an antihistamine drug, as a cholesterol trafficking inhibitor from a p...

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Detalles Bibliográficos
Autores principales: Lyu, Junfang, Yang, Eun Ju, Head, Sarah A., Ai, Nana, Zhang, Baoyuan, Wu, Changjie, Li, Ruo-Jing, Liu, Yifan, Chakravarty, Harapriya, Zhang, Shaolin, Tam, Kin Yip, Dang, Yongjun, Kwon, Ho Jeong, Ge, Wei, Liu, Jun O., Shim, Joong Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097475/
https://www.ncbi.nlm.nih.gov/pubmed/30123067
http://dx.doi.org/10.7150/ijbs.26011

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