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Aflatoxicosis in African greater cane rats (Thryonomys swinderianus)

AIM: Aflatoxicosis is a widespread problem in captive animals fed on stored food and has been reported in various animals both domestic and wild. This report documents the clinicopathologic, microbial diagnostic findings and therapeutic regime for a study on the presentation, management, and outcome...

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Autores principales: Jegede, Henry O., Akeem, Ahmed O., Daodu, Oluwafemi B., Adegboye, Afolabi A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Veterinary World 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097552/
https://www.ncbi.nlm.nih.gov/pubmed/30147272
http://dx.doi.org/10.14202/vetworld.2018.1001-1005
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author Jegede, Henry O.
Akeem, Ahmed O.
Daodu, Oluwafemi B.
Adegboye, Afolabi A.
author_facet Jegede, Henry O.
Akeem, Ahmed O.
Daodu, Oluwafemi B.
Adegboye, Afolabi A.
author_sort Jegede, Henry O.
collection PubMed
description AIM: Aflatoxicosis is a widespread problem in captive animals fed on stored food and has been reported in various animals both domestic and wild. This report documents the clinicopathologic, microbial diagnostic findings and therapeutic regime for a study on the presentation, management, and outcome of aflatoxicosis in greater cane rats. MATERIALS AND METHODS: A total of 65 greater cane rats suspected to be exposed to the toxin were examined clinically along with their environment. Feed samples, recently deceased carcasses and some moribund carcasses were collected for the study. Carcasses were subjected to gross and histopathologic investigations while feed and organs were subjected to microbiological investigations. RESULTS: Gross lesions included hepatic lipidosis with ecchymotic hemorrhages, distended gallbladder, and renomegaly with ecchymosis among others. Histopathology revealed loss of hepatocellular architecture with massive centrilobular hepatocyte necrosis and diffuse steatotic damage characterized by macrovacuoles. Other histologic findings included pulmonary congestion, moderate renal tubular degeneration, and necrosis of epithelial tubular cells. Aspergillus flavus was isolated from the feed and ingesta. Total aflatoxin detected in feed sample was found to be over 400 ppm. Klebsiella species, Staphylococcus species, and Bacillus species were isolated from the liver and intestinal content. Management was attempted using Fungizal(®) (Avico, Jordan) (which contains Thymol, benzoic acid, sorbic acid, and kaolin) and Orego-Stim(®) (Saife, USA) (which contains carvacrol and thymol) which were instituted in feed and Superliv(®) (Ayurvet, India) (polyherbal) liquid was instituted in water for 5 days at manufacturers’ dosage. All clinical signs disappeared, and no more deaths were recorded following management. CONCLUSION: This report concludes that aflatoxicosis causes severe mortality in greater cane rats and can be prevented and managed successfully.
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spelling pubmed-60975522018-08-24 Aflatoxicosis in African greater cane rats (Thryonomys swinderianus) Jegede, Henry O. Akeem, Ahmed O. Daodu, Oluwafemi B. Adegboye, Afolabi A. Vet World Research Article AIM: Aflatoxicosis is a widespread problem in captive animals fed on stored food and has been reported in various animals both domestic and wild. This report documents the clinicopathologic, microbial diagnostic findings and therapeutic regime for a study on the presentation, management, and outcome of aflatoxicosis in greater cane rats. MATERIALS AND METHODS: A total of 65 greater cane rats suspected to be exposed to the toxin were examined clinically along with their environment. Feed samples, recently deceased carcasses and some moribund carcasses were collected for the study. Carcasses were subjected to gross and histopathologic investigations while feed and organs were subjected to microbiological investigations. RESULTS: Gross lesions included hepatic lipidosis with ecchymotic hemorrhages, distended gallbladder, and renomegaly with ecchymosis among others. Histopathology revealed loss of hepatocellular architecture with massive centrilobular hepatocyte necrosis and diffuse steatotic damage characterized by macrovacuoles. Other histologic findings included pulmonary congestion, moderate renal tubular degeneration, and necrosis of epithelial tubular cells. Aspergillus flavus was isolated from the feed and ingesta. Total aflatoxin detected in feed sample was found to be over 400 ppm. Klebsiella species, Staphylococcus species, and Bacillus species were isolated from the liver and intestinal content. Management was attempted using Fungizal(®) (Avico, Jordan) (which contains Thymol, benzoic acid, sorbic acid, and kaolin) and Orego-Stim(®) (Saife, USA) (which contains carvacrol and thymol) which were instituted in feed and Superliv(®) (Ayurvet, India) (polyherbal) liquid was instituted in water for 5 days at manufacturers’ dosage. All clinical signs disappeared, and no more deaths were recorded following management. CONCLUSION: This report concludes that aflatoxicosis causes severe mortality in greater cane rats and can be prevented and managed successfully. Veterinary World 2018-07 2018-07-27 /pmc/articles/PMC6097552/ /pubmed/30147272 http://dx.doi.org/10.14202/vetworld.2018.1001-1005 Text en Copyright: © Jegede, et al. http://creativecommons.org/licenses/by/4.0 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Jegede, Henry O.
Akeem, Ahmed O.
Daodu, Oluwafemi B.
Adegboye, Afolabi A.
Aflatoxicosis in African greater cane rats (Thryonomys swinderianus)
title Aflatoxicosis in African greater cane rats (Thryonomys swinderianus)
title_full Aflatoxicosis in African greater cane rats (Thryonomys swinderianus)
title_fullStr Aflatoxicosis in African greater cane rats (Thryonomys swinderianus)
title_full_unstemmed Aflatoxicosis in African greater cane rats (Thryonomys swinderianus)
title_short Aflatoxicosis in African greater cane rats (Thryonomys swinderianus)
title_sort aflatoxicosis in african greater cane rats (thryonomys swinderianus)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097552/
https://www.ncbi.nlm.nih.gov/pubmed/30147272
http://dx.doi.org/10.14202/vetworld.2018.1001-1005
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