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Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat

Wheat is an important staple grain for humankind globally because of its end-use quality and nutritional properties and its adaptability to diverse climates. For a small proportion of the population, specific wheat proteins can trigger adverse immune responses and clinical manifestations such as cel...

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Autores principales: Juhász, Angéla, Belova, Tatiana, Florides, Chris G., Maulis, Csaba, Fischer, Iris, Gell, Gyöngyvér, Birinyi, Zsófia, Ong, Jamie, Keeble-Gagnère, Gabriel, Maharajan, Amudha, Ma, Wujun, Gibson, Peter, Jia, Jizeng, Lang, Daniel, Mayer, Klaus F. X., Spannagl, Manuel, Tye-Din, Jason A., Appels, Rudi, Olsen, Odd-Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097586/
https://www.ncbi.nlm.nih.gov/pubmed/30128352
http://dx.doi.org/10.1126/sciadv.aar8602
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author Juhász, Angéla
Belova, Tatiana
Florides, Chris G.
Maulis, Csaba
Fischer, Iris
Gell, Gyöngyvér
Birinyi, Zsófia
Ong, Jamie
Keeble-Gagnère, Gabriel
Maharajan, Amudha
Ma, Wujun
Gibson, Peter
Jia, Jizeng
Lang, Daniel
Mayer, Klaus F. X.
Spannagl, Manuel
Tye-Din, Jason A.
Appels, Rudi
Olsen, Odd-Arne
author_facet Juhász, Angéla
Belova, Tatiana
Florides, Chris G.
Maulis, Csaba
Fischer, Iris
Gell, Gyöngyvér
Birinyi, Zsófia
Ong, Jamie
Keeble-Gagnère, Gabriel
Maharajan, Amudha
Ma, Wujun
Gibson, Peter
Jia, Jizeng
Lang, Daniel
Mayer, Klaus F. X.
Spannagl, Manuel
Tye-Din, Jason A.
Appels, Rudi
Olsen, Odd-Arne
author_sort Juhász, Angéla
collection PubMed
description Wheat is an important staple grain for humankind globally because of its end-use quality and nutritional properties and its adaptability to diverse climates. For a small proportion of the population, specific wheat proteins can trigger adverse immune responses and clinical manifestations such as celiac disease, wheat allergy, baker’s asthma, and wheat-dependent exercise-induced anaphylaxis (WDEIA). Establishing the content and distribution of the immunostimulatory regions in wheat has been hampered by the complexity of the wheat genome and the lack of complete genome sequence information. We provide novel insights into the wheat grain proteins based on a comprehensive analysis and annotation of the wheat prolamin Pfam clan grain proteins and other non-prolamin allergens implicated in these disorders using the new International Wheat Genome Sequencing Consortium bread wheat reference genome sequence, RefSeq v1.0. Celiac disease and WDEIA genes are primarily expressed in the starchy endosperm and show wide variation in protein- and transcript-level expression in response to temperature stress. Nonspecific lipid transfer proteins and α-amylase trypsin inhibitor gene families, implicated in baker’s asthma, are primarily expressed in the aleurone layer and transfer cells of grains and are more sensitive to cold temperature. The study establishes a new reference map for immunostimulatory wheat proteins and provides a fresh basis for selecting wheat lines and developing diagnostics for products with more favorable consumer attributes.
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spelling pubmed-60975862018-08-20 Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat Juhász, Angéla Belova, Tatiana Florides, Chris G. Maulis, Csaba Fischer, Iris Gell, Gyöngyvér Birinyi, Zsófia Ong, Jamie Keeble-Gagnère, Gabriel Maharajan, Amudha Ma, Wujun Gibson, Peter Jia, Jizeng Lang, Daniel Mayer, Klaus F. X. Spannagl, Manuel Tye-Din, Jason A. Appels, Rudi Olsen, Odd-Arne Sci Adv Research Articles Wheat is an important staple grain for humankind globally because of its end-use quality and nutritional properties and its adaptability to diverse climates. For a small proportion of the population, specific wheat proteins can trigger adverse immune responses and clinical manifestations such as celiac disease, wheat allergy, baker’s asthma, and wheat-dependent exercise-induced anaphylaxis (WDEIA). Establishing the content and distribution of the immunostimulatory regions in wheat has been hampered by the complexity of the wheat genome and the lack of complete genome sequence information. We provide novel insights into the wheat grain proteins based on a comprehensive analysis and annotation of the wheat prolamin Pfam clan grain proteins and other non-prolamin allergens implicated in these disorders using the new International Wheat Genome Sequencing Consortium bread wheat reference genome sequence, RefSeq v1.0. Celiac disease and WDEIA genes are primarily expressed in the starchy endosperm and show wide variation in protein- and transcript-level expression in response to temperature stress. Nonspecific lipid transfer proteins and α-amylase trypsin inhibitor gene families, implicated in baker’s asthma, are primarily expressed in the aleurone layer and transfer cells of grains and are more sensitive to cold temperature. The study establishes a new reference map for immunostimulatory wheat proteins and provides a fresh basis for selecting wheat lines and developing diagnostics for products with more favorable consumer attributes. American Association for the Advancement of Science 2018-08-17 /pmc/articles/PMC6097586/ /pubmed/30128352 http://dx.doi.org/10.1126/sciadv.aar8602 Text en Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Juhász, Angéla
Belova, Tatiana
Florides, Chris G.
Maulis, Csaba
Fischer, Iris
Gell, Gyöngyvér
Birinyi, Zsófia
Ong, Jamie
Keeble-Gagnère, Gabriel
Maharajan, Amudha
Ma, Wujun
Gibson, Peter
Jia, Jizeng
Lang, Daniel
Mayer, Klaus F. X.
Spannagl, Manuel
Tye-Din, Jason A.
Appels, Rudi
Olsen, Odd-Arne
Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
title Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
title_full Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
title_fullStr Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
title_full_unstemmed Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
title_short Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
title_sort genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097586/
https://www.ncbi.nlm.nih.gov/pubmed/30128352
http://dx.doi.org/10.1126/sciadv.aar8602
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