Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

The poor correlation of mutational landscapes with phenotypes limits our understanding of pancreatic ductal adenocarcinoma (PDAC) pathogenesis and metastasis. Here we show a critical role of oncogenic dosage-variation in PDAC biology and phenotypic diversification. We found gene-dosage increase of m...

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Detalles Bibliográficos
Autores principales: Mueller, Sebastian, Engleitner, Thomas, Maresch, Roman, Zukowska, Magdalena, Lange, Sebastian, Kaltenbacher, Thorsten, Konukiewitz, Björn, Öllinger, Rupert, Zwiebel, Maximilian, Strong, Alex, Yen, Hsi-Yu, Banerjee, Ruby, Louzada, Sandra, Fu, Beiyuan, Seidler, Barbara, Götzfried, Juliana, Schuck, Kathleen, Hassan, Zonera, Arbeiter, Andreas, Schönhuber, Nina, Klein, Sabine, Veltkamp, Christian, Friedrich, Mathias, Rad, Lena, Barenboim, Maxim, Ziegenhain, Christoph, Hess, Julia, Dovey, Oliver M., Eser, Stefan, Parekh, Swati, Constantino-Casas, Fernando, de la Rosa, Jorge, Sierra, Marta I., Fraga, Mario, Mayerle, Julia, Klöppel, Günter, Cadiñanos, Juan, Liu, Pentao, Vassiliou, George, Weichert, Wilko, Steiger, Katja, Enard, Wolfgang, Schmid, Roland M., Yang, Fengtang, Unger, Kristian, Schneider, Günter, Varela, Ignacio, Bradley, Allan, Saur, Dieter, Rad, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097607/
https://www.ncbi.nlm.nih.gov/pubmed/29364867
http://dx.doi.org/10.1038/nature25459

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