Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175(+/-) mouse model of Huntington’s Disease

Huntington’s Disease (HD) is an autosomal dominant, progressive neurodegenerative disorder caused by deleterious expansion of CAG repeats in the Huntingtin gene and production of neurotoxic mutant Huntingtin protein (mHTT). The key pathological feature of HD is a profound degeneration of the striatu...

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Detalles Bibliográficos
Autores principales: Goodliffe, Joseph W., Song, Hanbing, Rubakovic, Anastasia, Chang, Wayne, Medalla, Maria, Weaver, Christina M., Luebke, Jennifer I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097649/
https://www.ncbi.nlm.nih.gov/pubmed/30118496
http://dx.doi.org/10.1371/journal.pone.0200626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097649/
https://www.ncbi.nlm.nih.gov/pubmed/30118496
http://dx.doi.org/10.1371/journal.pone.0200626

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