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A Bayesian measure of association that utilizes the underlying distributions of noise and information
We propose a new approach, Bayesian Probability of Association (BPA) which takes into account the probability distributions of information and noise in the variables and uses Bayesian statistics to predict associations better than existing approaches. Our approach overcomes the limitations of linear...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097650/ https://www.ncbi.nlm.nih.gov/pubmed/30118488 http://dx.doi.org/10.1371/journal.pone.0201185 |
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author | Goel, Ishan Khurana, Sukant |
author_facet | Goel, Ishan Khurana, Sukant |
author_sort | Goel, Ishan |
collection | PubMed |
description | We propose a new approach, Bayesian Probability of Association (BPA) which takes into account the probability distributions of information and noise in the variables and uses Bayesian statistics to predict associations better than existing approaches. Our approach overcomes the limitations of linearity of the relationship and normality of the data, assumed by the Pearson correlation coefficient. It is different from the current measures of association because considering information separately from noise helps identify the association in information more accurately, makes the approach less sensitive to noise and also helps identify causal directions. We tested the approach on 15 datasets with no underlying association and on 75 datasets with known causal relationships and compared the results with other measures of association. No false associations were detected and true associations were predicted in more than 90% cases whereas the Pearson correlation coefficient and mutual information content predicted associations for less than half of the datasets. |
format | Online Article Text |
id | pubmed-6097650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-60976502018-08-30 A Bayesian measure of association that utilizes the underlying distributions of noise and information Goel, Ishan Khurana, Sukant PLoS One Research Article We propose a new approach, Bayesian Probability of Association (BPA) which takes into account the probability distributions of information and noise in the variables and uses Bayesian statistics to predict associations better than existing approaches. Our approach overcomes the limitations of linearity of the relationship and normality of the data, assumed by the Pearson correlation coefficient. It is different from the current measures of association because considering information separately from noise helps identify the association in information more accurately, makes the approach less sensitive to noise and also helps identify causal directions. We tested the approach on 15 datasets with no underlying association and on 75 datasets with known causal relationships and compared the results with other measures of association. No false associations were detected and true associations were predicted in more than 90% cases whereas the Pearson correlation coefficient and mutual information content predicted associations for less than half of the datasets. Public Library of Science 2018-08-17 /pmc/articles/PMC6097650/ /pubmed/30118488 http://dx.doi.org/10.1371/journal.pone.0201185 Text en © 2018 Goel, Khurana http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Goel, Ishan Khurana, Sukant A Bayesian measure of association that utilizes the underlying distributions of noise and information |
title | A Bayesian measure of association that utilizes the underlying distributions of noise and information |
title_full | A Bayesian measure of association that utilizes the underlying distributions of noise and information |
title_fullStr | A Bayesian measure of association that utilizes the underlying distributions of noise and information |
title_full_unstemmed | A Bayesian measure of association that utilizes the underlying distributions of noise and information |
title_short | A Bayesian measure of association that utilizes the underlying distributions of noise and information |
title_sort | bayesian measure of association that utilizes the underlying distributions of noise and information |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097650/ https://www.ncbi.nlm.nih.gov/pubmed/30118488 http://dx.doi.org/10.1371/journal.pone.0201185 |
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