Cargando…

A Bayesian measure of association that utilizes the underlying distributions of noise and information

We propose a new approach, Bayesian Probability of Association (BPA) which takes into account the probability distributions of information and noise in the variables and uses Bayesian statistics to predict associations better than existing approaches. Our approach overcomes the limitations of linear...

Descripción completa

Detalles Bibliográficos
Autores principales: Goel, Ishan, Khurana, Sukant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097650/
https://www.ncbi.nlm.nih.gov/pubmed/30118488
http://dx.doi.org/10.1371/journal.pone.0201185
_version_ 1783348338027921408
author Goel, Ishan
Khurana, Sukant
author_facet Goel, Ishan
Khurana, Sukant
author_sort Goel, Ishan
collection PubMed
description We propose a new approach, Bayesian Probability of Association (BPA) which takes into account the probability distributions of information and noise in the variables and uses Bayesian statistics to predict associations better than existing approaches. Our approach overcomes the limitations of linearity of the relationship and normality of the data, assumed by the Pearson correlation coefficient. It is different from the current measures of association because considering information separately from noise helps identify the association in information more accurately, makes the approach less sensitive to noise and also helps identify causal directions. We tested the approach on 15 datasets with no underlying association and on 75 datasets with known causal relationships and compared the results with other measures of association. No false associations were detected and true associations were predicted in more than 90% cases whereas the Pearson correlation coefficient and mutual information content predicted associations for less than half of the datasets.
format Online
Article
Text
id pubmed-6097650
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-60976502018-08-30 A Bayesian measure of association that utilizes the underlying distributions of noise and information Goel, Ishan Khurana, Sukant PLoS One Research Article We propose a new approach, Bayesian Probability of Association (BPA) which takes into account the probability distributions of information and noise in the variables and uses Bayesian statistics to predict associations better than existing approaches. Our approach overcomes the limitations of linearity of the relationship and normality of the data, assumed by the Pearson correlation coefficient. It is different from the current measures of association because considering information separately from noise helps identify the association in information more accurately, makes the approach less sensitive to noise and also helps identify causal directions. We tested the approach on 15 datasets with no underlying association and on 75 datasets with known causal relationships and compared the results with other measures of association. No false associations were detected and true associations were predicted in more than 90% cases whereas the Pearson correlation coefficient and mutual information content predicted associations for less than half of the datasets. Public Library of Science 2018-08-17 /pmc/articles/PMC6097650/ /pubmed/30118488 http://dx.doi.org/10.1371/journal.pone.0201185 Text en © 2018 Goel, Khurana http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Goel, Ishan
Khurana, Sukant
A Bayesian measure of association that utilizes the underlying distributions of noise and information
title A Bayesian measure of association that utilizes the underlying distributions of noise and information
title_full A Bayesian measure of association that utilizes the underlying distributions of noise and information
title_fullStr A Bayesian measure of association that utilizes the underlying distributions of noise and information
title_full_unstemmed A Bayesian measure of association that utilizes the underlying distributions of noise and information
title_short A Bayesian measure of association that utilizes the underlying distributions of noise and information
title_sort bayesian measure of association that utilizes the underlying distributions of noise and information
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097650/
https://www.ncbi.nlm.nih.gov/pubmed/30118488
http://dx.doi.org/10.1371/journal.pone.0201185
work_keys_str_mv AT goelishan abayesianmeasureofassociationthatutilizestheunderlyingdistributionsofnoiseandinformation
AT khuranasukant abayesianmeasureofassociationthatutilizestheunderlyingdistributionsofnoiseandinformation
AT goelishan bayesianmeasureofassociationthatutilizestheunderlyingdistributionsofnoiseandinformation
AT khuranasukant bayesianmeasureofassociationthatutilizestheunderlyingdistributionsofnoiseandinformation