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Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation

Paired-pulse depression (PPD) has been widely used to investigate the functional profiles of somatosensory cortical inhibition. However, PPD induced by somatosensory stimulation is variable, and the reasons for between- and within-subject PPD variability remains unclear. Therefore, the purpose of th...

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Autores principales: Onishi, Hideaki, Otsuru, Naofumi, Kojima, Sho, Miyaguchi, Shota, Saito, Kei, Inukai, Yasuto, Yamashiro, Koya, Sato, Daisuke, Tamaki, Hiroyuki, Shirozu, Hiroshi, Kameyama, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097743/
https://www.ncbi.nlm.nih.gov/pubmed/29737438
http://dx.doi.org/10.1007/s10548-018-0648-5
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author Onishi, Hideaki
Otsuru, Naofumi
Kojima, Sho
Miyaguchi, Shota
Saito, Kei
Inukai, Yasuto
Yamashiro, Koya
Sato, Daisuke
Tamaki, Hiroyuki
Shirozu, Hiroshi
Kameyama, Shigeki
author_facet Onishi, Hideaki
Otsuru, Naofumi
Kojima, Sho
Miyaguchi, Shota
Saito, Kei
Inukai, Yasuto
Yamashiro, Koya
Sato, Daisuke
Tamaki, Hiroyuki
Shirozu, Hiroshi
Kameyama, Shigeki
author_sort Onishi, Hideaki
collection PubMed
description Paired-pulse depression (PPD) has been widely used to investigate the functional profiles of somatosensory cortical inhibition. However, PPD induced by somatosensory stimulation is variable, and the reasons for between- and within-subject PPD variability remains unclear. Therefore, the purpose of this study was to clarify the factors influencing PPD variability induced by somatosensory stimulation. The study participants were 19 healthy volunteers. First, we investigated the relationship between the PPD ratio of each component (N20m, P35m, and P60m) of the somatosensory magnetic field, and the alpha, beta, and gamma band changes in power [event-related desynchronization (ERD) and event-related synchronization (ERS)] induced by median nerve stimulation. Second, because brain-derived neurotrophic factor (BDNF) gene polymorphisms reportedly influence the PPD ratio, we assessed whether BDNF genotype influences PPD ratio variability. Finally, we evaluated the test–retest reliability of PPD and the alpha, beta, and gamma ERD/ERS induced by somatosensory stimulation. Significant positive correlations were observed between the P60m_PPD ratio and beta power change, and the P60m_PPD ratio was significantly smaller for the beta ERD group than for the beta ERS group. P35m_PPD was found to be robust and highly reproducible; however, P60m_PPD reproducibility was poor. In addition, the ICC values for alpha, beta, and gamma ERD/ERS were 0.680, 0.760, and 0.552 respectively. These results suggest that the variability of PPD for the P60m deflection may be influenced by the ERD/ERS magnitude, which is induced by median nerve stimulation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10548-018-0648-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-60977432018-08-24 Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation Onishi, Hideaki Otsuru, Naofumi Kojima, Sho Miyaguchi, Shota Saito, Kei Inukai, Yasuto Yamashiro, Koya Sato, Daisuke Tamaki, Hiroyuki Shirozu, Hiroshi Kameyama, Shigeki Brain Topogr Original Paper Paired-pulse depression (PPD) has been widely used to investigate the functional profiles of somatosensory cortical inhibition. However, PPD induced by somatosensory stimulation is variable, and the reasons for between- and within-subject PPD variability remains unclear. Therefore, the purpose of this study was to clarify the factors influencing PPD variability induced by somatosensory stimulation. The study participants were 19 healthy volunteers. First, we investigated the relationship between the PPD ratio of each component (N20m, P35m, and P60m) of the somatosensory magnetic field, and the alpha, beta, and gamma band changes in power [event-related desynchronization (ERD) and event-related synchronization (ERS)] induced by median nerve stimulation. Second, because brain-derived neurotrophic factor (BDNF) gene polymorphisms reportedly influence the PPD ratio, we assessed whether BDNF genotype influences PPD ratio variability. Finally, we evaluated the test–retest reliability of PPD and the alpha, beta, and gamma ERD/ERS induced by somatosensory stimulation. Significant positive correlations were observed between the P60m_PPD ratio and beta power change, and the P60m_PPD ratio was significantly smaller for the beta ERD group than for the beta ERS group. P35m_PPD was found to be robust and highly reproducible; however, P60m_PPD reproducibility was poor. In addition, the ICC values for alpha, beta, and gamma ERD/ERS were 0.680, 0.760, and 0.552 respectively. These results suggest that the variability of PPD for the P60m deflection may be influenced by the ERD/ERS magnitude, which is induced by median nerve stimulation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10548-018-0648-5) contains supplementary material, which is available to authorized users. Springer US 2018-05-08 2018 /pmc/articles/PMC6097743/ /pubmed/29737438 http://dx.doi.org/10.1007/s10548-018-0648-5 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Onishi, Hideaki
Otsuru, Naofumi
Kojima, Sho
Miyaguchi, Shota
Saito, Kei
Inukai, Yasuto
Yamashiro, Koya
Sato, Daisuke
Tamaki, Hiroyuki
Shirozu, Hiroshi
Kameyama, Shigeki
Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation
title Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation
title_full Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation
title_fullStr Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation
title_full_unstemmed Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation
title_short Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation
title_sort variability and reliability of paired-pulse depression and cortical oscillation induced by median nerve stimulation
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097743/
https://www.ncbi.nlm.nih.gov/pubmed/29737438
http://dx.doi.org/10.1007/s10548-018-0648-5
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