Central nervous system localisation of chronic lymphocytic leukaemia, description of two very distinct cases and a review of the literature

Central nervous system (CNS) localisation of chronic lymphocytic leukaemia (CLL) can induce various neurological symptoms. Unfamiliarity with this manifestation causes diagnostic delay. We present two cases of leptomeningeal CLL. These cases and our literature review emphasise that CNS localisation...

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Detalles Bibliográficos
Autores principales: Timmers, Nyanza K. L. M., de Maar, Josanne S., van Kruijsdijk, Rob C. M., Klein, Saskia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097746/
https://www.ncbi.nlm.nih.gov/pubmed/29707738
http://dx.doi.org/10.1007/s00277-018-3329-2
Descripción
Sumario:Central nervous system (CNS) localisation of chronic lymphocytic leukaemia (CLL) can induce various neurological symptoms. Unfamiliarity with this manifestation causes diagnostic delay. We present two cases of leptomeningeal CLL. These cases and our literature review emphasise that CNS localisation of CLL should be considered in patients with any neurological symptom, irrespectively of the stage and systemic activity of CLL. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00277-018-3329-2) contains supplementary material, which is available to authorized users.

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