Central nervous system localisation of chronic lymphocytic leukaemia, description of two very distinct cases and a review of the literature

Central nervous system (CNS) localisation of chronic lymphocytic leukaemia (CLL) can induce various neurological symptoms. Unfamiliarity with this manifestation causes diagnostic delay. We present two cases of leptomeningeal CLL. These cases and our literature review emphasise that CNS localisation...

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Autores principales: Timmers, Nyanza K. L. M., de Maar, Josanne S., van Kruijsdijk, Rob C. M., Klein, Saskia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097746/
https://www.ncbi.nlm.nih.gov/pubmed/29707738
http://dx.doi.org/10.1007/s00277-018-3329-2
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author Timmers, Nyanza K. L. M.
de Maar, Josanne S.
van Kruijsdijk, Rob C. M.
Klein, Saskia K.
author_facet Timmers, Nyanza K. L. M.
de Maar, Josanne S.
van Kruijsdijk, Rob C. M.
Klein, Saskia K.
author_sort Timmers, Nyanza K. L. M.
collection PubMed
description Central nervous system (CNS) localisation of chronic lymphocytic leukaemia (CLL) can induce various neurological symptoms. Unfamiliarity with this manifestation causes diagnostic delay. We present two cases of leptomeningeal CLL. These cases and our literature review emphasise that CNS localisation of CLL should be considered in patients with any neurological symptom, irrespectively of the stage and systemic activity of CLL. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00277-018-3329-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-60977462018-08-24 Central nervous system localisation of chronic lymphocytic leukaemia, description of two very distinct cases and a review of the literature Timmers, Nyanza K. L. M. de Maar, Josanne S. van Kruijsdijk, Rob C. M. Klein, Saskia K. Ann Hematol Original Article Central nervous system (CNS) localisation of chronic lymphocytic leukaemia (CLL) can induce various neurological symptoms. Unfamiliarity with this manifestation causes diagnostic delay. We present two cases of leptomeningeal CLL. These cases and our literature review emphasise that CNS localisation of CLL should be considered in patients with any neurological symptom, irrespectively of the stage and systemic activity of CLL. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00277-018-3329-2) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2018-04-29 2018 /pmc/articles/PMC6097746/ /pubmed/29707738 http://dx.doi.org/10.1007/s00277-018-3329-2 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Timmers, Nyanza K. L. M.
de Maar, Josanne S.
van Kruijsdijk, Rob C. M.
Klein, Saskia K.
Central nervous system localisation of chronic lymphocytic leukaemia, description of two very distinct cases and a review of the literature
title Central nervous system localisation of chronic lymphocytic leukaemia, description of two very distinct cases and a review of the literature
title_full Central nervous system localisation of chronic lymphocytic leukaemia, description of two very distinct cases and a review of the literature
title_fullStr Central nervous system localisation of chronic lymphocytic leukaemia, description of two very distinct cases and a review of the literature
title_full_unstemmed Central nervous system localisation of chronic lymphocytic leukaemia, description of two very distinct cases and a review of the literature
title_short Central nervous system localisation of chronic lymphocytic leukaemia, description of two very distinct cases and a review of the literature
title_sort central nervous system localisation of chronic lymphocytic leukaemia, description of two very distinct cases and a review of the literature
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097746/
https://www.ncbi.nlm.nih.gov/pubmed/29707738
http://dx.doi.org/10.1007/s00277-018-3329-2
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