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Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior

Given that addiction has been characterized as a disorder of maladaptive learning and memory, one critical question is whether there are unique physical adaptations within neuronal ensembles that support addiction-related learned behavior. The search for the physical mechanisms of encoding these and...

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Detalles Bibliográficos
Autores principales: Whitaker, Leslie R., Hope, Bruce T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097770/
https://www.ncbi.nlm.nih.gov/pubmed/30115767
http://dx.doi.org/10.1101/lm.046698.117
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author Whitaker, Leslie R.
Hope, Bruce T.
author_facet Whitaker, Leslie R.
Hope, Bruce T.
author_sort Whitaker, Leslie R.
collection PubMed
description Given that addiction has been characterized as a disorder of maladaptive learning and memory, one critical question is whether there are unique physical adaptations within neuronal ensembles that support addiction-related learned behavior. The search for the physical mechanisms of encoding these and other memories in the brain, often called the engram as a whole, continues despite decades of research. As we develop new technologies and tools that allow us to study cue- and behavior-activated Fos-expressing neuronal ensembles, the possibility of identifying the engrams of learning and memory is moving into the realm of reality rather than speculation. It has become clear from recent studies that there are specific functional, electrophysiological alterations unique to Fos-expressing ensemble neurons that may participate in encoding memories. The ultimate goal is to identify the addicted engram and reverse the physical changes that support this maladaptive form of learning.
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spelling pubmed-60977702019-09-01 Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior Whitaker, Leslie R. Hope, Bruce T. Learn Mem Review Given that addiction has been characterized as a disorder of maladaptive learning and memory, one critical question is whether there are unique physical adaptations within neuronal ensembles that support addiction-related learned behavior. The search for the physical mechanisms of encoding these and other memories in the brain, often called the engram as a whole, continues despite decades of research. As we develop new technologies and tools that allow us to study cue- and behavior-activated Fos-expressing neuronal ensembles, the possibility of identifying the engrams of learning and memory is moving into the realm of reality rather than speculation. It has become clear from recent studies that there are specific functional, electrophysiological alterations unique to Fos-expressing ensemble neurons that may participate in encoding memories. The ultimate goal is to identify the addicted engram and reverse the physical changes that support this maladaptive form of learning. Cold Spring Harbor Laboratory Press 2018-09 /pmc/articles/PMC6097770/ /pubmed/30115767 http://dx.doi.org/10.1101/lm.046698.117 Text en Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This is a work of the US Government.
spellingShingle Review
Whitaker, Leslie R.
Hope, Bruce T.
Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior
title Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior
title_full Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior
title_fullStr Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior
title_full_unstemmed Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior
title_short Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior
title_sort chasing the addicted engram: identifying functional alterations in fos-expressing neuronal ensembles that mediate drug-related learned behavior
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097770/
https://www.ncbi.nlm.nih.gov/pubmed/30115767
http://dx.doi.org/10.1101/lm.046698.117
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