The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation

While menin plays an important role in preventing T-cell dysfunction, such as senescence and exhaustion, the regulatory mechanisms remain unclear. We found that menin prevents the induction of dysfunction in activated CD8 T cells by restricting the cellular metabolism. mTOR complex 1 (mTORC1) signal...

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Detalles Bibliográficos
Autores principales: Suzuki, Junpei, Yamada, Takeshi, Inoue, Kazuki, Nabe, Shogo, Kuwahara, Makoto, Takemori, Nobuaki, Takemori, Ayako, Matsuda, Seiji, Kanoh, Makoto, Imai, Yuuki, Yasukawa, Masaki, Yamashita, Masakatsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098065/
https://www.ncbi.nlm.nih.gov/pubmed/30120246
http://dx.doi.org/10.1038/s41467-018-05854-6

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