Coupled Transmembrane Substrate Docking and Helical Unwinding in Intramembrane Proteolysis of Amyloid Precursor Protein

Intramembrane-cleaving proteases (I-CLiPs) play crucial roles in physiological and pathological processes, such as Alzheimer’s disease and cancer. However, the mechanisms of substrate recognition by I-CLiPs remain poorly understood. The aspartic I-CLiP presenilin is the catalytic subunit of the γ-se...

Descripción completa

Detalles Bibliográficos
Autores principales: Clemente, Nicolina, Abdine, Alaa, Ubarretxena-Belandia, Iban, Wang, Chunyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098081/
https://www.ncbi.nlm.nih.gov/pubmed/30120254
http://dx.doi.org/10.1038/s41598-018-30015-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098081/
https://www.ncbi.nlm.nih.gov/pubmed/30120254
http://dx.doi.org/10.1038/s41598-018-30015-6

Ejemplares similares